USP1 and FANCD2

Number of citations of the paper that reports this interaction (PubMedID 15694335)
240

Data Source:
BioGRID (enzymatic study)
HPRD (in vivo)

		USP1	FANCD2
Description		ubiquitin specific peptidase 1	FA complementation group D2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Condensed Chromosome Nucleus Nucleoplasm Nucleolus Cytosol Nuclear Body
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding Peptidase Activity	Protein Binding DNA Polymerase Binding
	Biological Process	Skeletal System Development DNA Repair Regulation Of DNA Repair Ubiquitin-dependent Protein Catabolic Process Response To UV Protein Deubiquitination Monoubiquitinated Protein Deubiquitination DNA Damage Response, Detection Of DNA Damage	Homologous Chromosome Pairing At Meiosis Response To Gamma Radiation Mitotic Intra-S DNA Damage Checkpoint Signaling Interstrand Cross-link Repair Double-strand Break Repair Involved In Meiotic Recombination
Pathways		Recognition of DNA damage by PCNA-containing replication complex Fanconi Anemia Pathway	Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes
Drugs
Diseases
GWAS		Crohn's disease ( 26192919 28067908) Lipid traits ( 24386095) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 31589552) Red blood cell count ( 32888494) Regular attendance at a gym or sports club ( 29970889) Serum metabolite levels (CMS) ( 31636271) Triglyceride levels ( 32203549) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)	Alzheimer's disease ( 24755620) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		16 interacting genes: DTX3 EZH2 EZR FANCD2 FANCI KLHDC2 KPNA1 NMRAL1 PCNA PHF7 TRAF6 TRIM46 UBB UBC UBE2K WDR48	30 interacting genes: ATM ATR BLM BRCA1 BRCA2 BRIP1 FANCC FANCE FANCI FANCL H2AC4 H2BC3 H3C1 H4C1 MEN1 MRE11 NBN PCNA RAD51 TERF1 TNFRSF1A TNFRSF1B TNKS UBB UBE2T UHRF1 UHRF2 USP1 USP2 USP7
Entrez ID		7398	2177
HPRD ID		04593	01968
Ensembl ID		ENSG00000162607	ENSG00000144554
Uniprot IDs		O94782	Q9BXW9
PDB IDs		6DO5	6VAA 6VAD 6VAE 6VAF
Enriched GO Terms of Interacting Partners?
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