KPNA1 and RAG1

Number of citations of the paper that reports this interaction (PubMedID 8052633)
62

Data Source:
HPRD (in vitro, two hybrid)

		KPNA1	RAG1
Description		karyopherin subunit alpha 1	recombination activating 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Dendrite Glutamatergic Synapse	Nucleus Nucleoplasm DNA Recombinase Complex Endodeoxyribonuclease Complex
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity	DNA Binding Endonuclease Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Histone Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Double-stranded DNA Endodeoxyribonuclease Activity
	Biological Process	Regulation Of DNA Recombination NLS-bearing Protein Import Into Nucleus Skeletal Muscle Satellite Cell Proliferation Satellite Cell Activation Involved In Skeletal Muscle Regeneration Regulation Of Apoptotic Process Regulation Of Canonical Wnt Signaling Pathway Postsynapse To Nucleus Signaling Pathway	Adaptive Immune Response Pre-B Cell Allelic Exclusion DNA Recombination Immune Response Visual Learning Histone Monoubiquitination B Cell Differentiation T Cell Differentiation In Thymus V(D)J Recombination T Cell Homeostasis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of T Cell Differentiation Thymus Development Protein Autoubiquitination Negative Regulation Of Thymocyte Apoptotic Process Nucleic Acid Phosphodiester Bond Hydrolysis Regulation Of Behavioral Fear Response
Pathways		ISG15 antiviral mechanism Apoptosis induced DNA fragmentation Integration of provirus Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Vpr-mediated nuclear import of PICs Inhibition of nitric oxide production	Interleukin-7 signaling MAPK6/MAPK4 signaling
Drugs
Diseases
GWAS		Calcium levels ( 20705733) LDL cholesterol ( 30275531) LDL cholesterol levels ( 28334899) Mean corpuscular hemoglobin ( 32888494) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Rheumatoid arthritis ( 24390342)
Interacting Genes		46 interacting genes: ANP32A ANP32B ARNT BCAR3 CD86 CDKN1B CLK4 CRADD CSE1L ELAVL1 EPAS1 FOSL1 GOPC GTF2IRD1 H2BC21 H3-4 HDAC6 HIF1A IL1RAP KPNB1 LEF1 LINC01554 LMO4 MACROD1 MDM2 NMNAT1 NOSIP NUP50 NUP54 NUP62 OGT ORC4 PAX5 PKM POLR3C RAG1 RANBP2 RUNX1T1 SENP2 SKP2 SRP19 STAT1 STAT3 TAF9 UBR5 USP1	22 interacting genes: APOF APP CAPRIN1 DCAF1 H2AC20 H2BC21 H3-4 H3C1 H4-16 HMGB1 HMGB2 KPNA1 KPNA2 PAX6 RAG2 SNX6 TBCA UBC UBE2C UBE2D1 UBE2D2 UBE2H
Entrez ID		3836	5896
HPRD ID		02819	01556
Ensembl ID		ENSG00000114030	ENSG00000166349
Uniprot IDs		B3KXZ2 P52294	P15918
PDB IDs		2JDQ 3TJ3 4B18 6WX9
Enriched GO Terms of Interacting Partners?
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