KCNJ6 and BCL2L2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		KCNJ6	BCL2L2
Description		potassium inwardly rectifying channel subfamily J member 6	BCL2 like 2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Voltage-gated Potassium Channel Complex	Mitochondrial Outer Membrane Cytosol Bcl-2 Family Protein Complex
	Molecular Function	Inward Rectifier Potassium Channel Activity Protein Binding G-protein Activated Inward Rectifier Potassium Channel Activity	Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Protein Heterodimerization Activity BH Domain Binding Disordered Domain Specific Binding
	Biological Process	Potassium Ion Transport Regulation Of Ion Transmembrane Transport Potassium Ion Import Across Plasma Membrane	Response To Ischemia Spermatogenesis Brain Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Apoptotic Process Sertoli Cell Proliferation Cellular Response To Estradiol Stimulus Negative Regulation Of Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Response To Amyloid-beta Cellular Response To Glycine Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Activation of G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs		Ethanol Halothane Ifenprodil Isavuconazole	Navitoclax
Diseases
GWAS		Body size at age 10 ( 32376654) Clostridioides difficle infection ( 33841421) Electroencephalographic traits in alcoholism ( 22554406) Response to placebo treatment in childhood asthma (FVC change) ( 31557306) Rosacea symptom severity ( 29771307)	Height ( 28552196) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		64 interacting genes: ADRB2 AIG1 APOD BCL2L2 BET1 BIRC5 C14orf180 CMTM5 CNPY3 COL4A5 DLG1 DRD2 EDDM3B ERG28 FAM20B FIS1 FUNDC2 FXYD6 GABBR1 HMOX2 ICMT ITGAM KCNJ3 KCNJ9 LEPROTL1 LPAR3 LPCAT2 MIP MYO15B NINJ2 ORMDL2 PEX11G PEX16 PLLP PMP22 PNLIPRP1 RPRM RPS6KA2 RTP2 SCAMP4 SCARF1 SCD SERTM1 STATH STRIT1 SYT3 THSD7B TM6SF2 TMEM107 TMEM120B TMEM203 TMEM208 TMEM218 TMPPE TNFRSF10C TSPO2 UBIAD1 UNC50 UPK1B VSTM1 XIAP YIPF1 YIPF6 ZDHHC24	53 interacting genes: ANKS6 APOC1 APOC2 APOC4 ATP5PF BAD BAK1 BAX BBC3 BCL2L11 BHLHA9 BID BIK BMF BNIP3 BNIP5 C10orf67 CD79A CHODL CIDEB CISD2 CLDN7 ERVFRD-1 FATE1 G0S2 GORAB GPR151 GPX8 HRK KASH5 KCNJ6 LMNA LRRIQ1 MGST2 MUC1 PANX1 PPP1CA PSCA RHBDD2 S100B SAR1A SGPL1 SLC35C2 SLC35E3 SLC39A2 SLC39A6 STOM SUSD3 TCF4 TEX11 TMEM139 TMX1 TP53
Entrez ID		3763	599
HPRD ID		02929	03569
Ensembl ID		ENSG00000157542	ENSG00000129473
Uniprot IDs		P48051	Q92843
PDB IDs			1MK3 1O0L 1ZY3 2Y6W 4CIM
Enriched GO Terms of Interacting Partners?
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