INSIG1 and SREBF2

Number of citations of the paper that reports this interaction (PubMedID 12202038)
315

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro, in vivo)

		INSIG1	SREBF2
Description		insulin induced gene 1	sterol regulatory element binding transcription factor 2
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane SREBP-SCAP-Insig Complex	Golgi Membrane Chromatin Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane SREBP-SCAP-Insig Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Oxysterol Binding	C-8 Sterol Isomerase Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Protein C-terminus Binding Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Triglyceride Metabolic Process Cholesterol Biosynthetic Process Negative Regulation Of Steroid Biosynthetic Process Sterol Biosynthetic Process Cellular Response To Insulin Stimulus SREBP Signaling Pathway Cellular Response To Sterol SREBP-SCAP Complex Retention In Endoplasmic Reticulum Inner Ear Morphogenesis Middle Ear Morphogenesis Cholesterol Homeostasis Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Fatty Acid Biosynthetic Process Roof Of Mouth Development Cranial Suture Morphogenesis Negative Regulation Of Protein Exit From Endoplasmic Reticulum Negative Regulation Of Cargo Loading Into COPII-coated Vesicle	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Cholesterol Metabolic Process Regulation Of Notch Signaling Pathway Cellular Response To Starvation Positive Regulation Of Cholesterol Storage SREBP Signaling Pathway Cholesterol Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cholesterol Efflux Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF)	Regulation of cholesterol biosynthesis by SREBP (SREBF) Regulation of cholesterol biosynthesis by SREBP (SREBF) PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases
GWAS		Bladder cancer (smoking interaction) ( 24662972) Diverticular disease ( 30177863) Energy expenditure (24h) ( 28476931) Formal thought disorder in schizophrenia ( 22648509) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Plasma anti-thyroglobulin levels ( 29678681) Triiodothyronine levels and thyroxine levels ( 30843173)	Alanine aminotransferase levels ( 33547301) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Birth weight ( 31043758 27680694) Caffeine consumption from tea ( 33287642) General cognitive ability ( 29844566) Processed meat consumption ( 32066663) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		12 interacting genes: AQP6 BDKRB1 ELOC HMGCR HTR2B PCK1 PSMA7 PSMC3 SCAP SREBF2 TMEM237 VCP	50 interacting genes: ABLIM1 ABLIM2 ARHGEF1 ARRB1 ATF7IP ATXN1 AURKA CASP3 CASP8AP2 COPS5 CREB1 CREBBP EGR1 EP300 FHL2 FHL3 GOLGB1 HNF4A HSPA5 INSIG1 INSIG2 ITGB4 KLF13 KPNB1 LINC00839 LZTR1 MAPK1 MAPK3 MRPS6 MTNR1B NAE1 NFYA NFYC OS9 PIAS1 PIAS2 PIAS3 PSMD4 RAB11B SCAP SLC4A4 SMAD3 SP1 SPTBN1 SUMO1 TTC1 UBE2I ZDHHC17 ZMYM2 ZYX
Entrez ID		3638	6721
HPRD ID		03633	02726
Ensembl ID		ENSG00000186480	ENSG00000198911
Uniprot IDs		A0A024RD68 A4D2M9 F5H6P3 O15503	A0A024R1Q0 Q12772
PDB IDs		4J81	1UKL
Enriched GO Terms of Interacting Partners?
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