INSIG1 and SCAP

Number of citations of the paper that reports this interaction (PubMedID 12202038)
315

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, in vitro)

		INSIG1	SCAP
Description		insulin induced gene 1	SREBF chaperone
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane SREBP-SCAP-Insig Complex	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Protein-containing Complex
	Molecular Function	Protein Binding Oxysterol Binding	Protein Binding Sterol Binding Protein-containing Complex Binding Unfolded Protein Binding
	Biological Process	Triglyceride Metabolic Process Cholesterol Biosynthetic Process Negative Regulation Of Steroid Biosynthetic Process Sterol Biosynthetic Process Cellular Response To Insulin Stimulus SREBP Signaling Pathway Cellular Response To Sterol SREBP-SCAP Complex Retention In Endoplasmic Reticulum Inner Ear Morphogenesis Middle Ear Morphogenesis Cholesterol Homeostasis Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Fatty Acid Biosynthetic Process Roof Of Mouth Development Cranial Suture Morphogenesis Negative Regulation Of Protein Exit From Endoplasmic Reticulum Negative Regulation Of Cargo Loading Into COPII-coated Vesicle	Response To Hypoxia Immune Response Aging Cholesterol Metabolic Process Response To Insulin SREBP Signaling Pathway Regulation Of Fatty Acid Biosynthetic Process Cellular Lipid Metabolic Process Negative Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process COPII-coated Vesicle Cargo Loading
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF)	Regulation of cholesterol biosynthesis by SREBP (SREBF) Regulation of cholesterol biosynthesis by SREBP (SREBF)
Drugs
Diseases
GWAS		Bladder cancer (smoking interaction) ( 24662972) Diverticular disease ( 30177863) Energy expenditure (24h) ( 28476931) Formal thought disorder in schizophrenia ( 22648509) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Plasma anti-thyroglobulin levels ( 29678681) Triiodothyronine levels and thyroxine levels ( 30843173)	Refractive error ( 32231278) Triglyceride levels ( 32203549)
Interacting Genes		12 interacting genes: AQP6 BDKRB1 ELOC HMGCR HTR2B PCK1 PSMA7 PSMC3 SCAP SREBF2 TMEM237 VCP	12 interacting genes: ATG16L1 DHX30 HIPK2 INSIG1 INSIG2 KLHL18 LAMC2 NDUFAF3 PGRMC1 SEC24B SREBF2 WDR6
Entrez ID		3638	22937
HPRD ID		03633	03300
Ensembl ID		ENSG00000186480	ENSG00000114650
Uniprot IDs		A0A024RD68 A4D2M9 F5H6P3 O15503	B7Z6H0 Q12770
PDB IDs		4J81	6M49
Enriched GO Terms of Interacting Partners?
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