IGHM and MAP3K20

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		IGHM	MAP3K20
Description		immunoglobulin heavy constant mu	mitogen-activated protein kinase kinase kinase 20
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Immunoglobulin Complex, Circulating Extracellular Exosome Pentameric IgM Immunoglobulin Complex Hexameric IgM Immunoglobulin Complex Blood Microparticle	Nucleus Cytoplasm Cytosol
	Molecular Function	Single-stranded DNA Binding Antigen Binding Phosphatidylcholine Binding Immunoglobulin Receptor Binding Peptidoglycan Binding	Magnesium Ion Binding RNA Binding MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	Adaptive Immune Response Phagocytosis, Recognition Phagocytosis, Engulfment Complement Activation, Classical Pathway Antibacterial Humoral Response Defense Response To Bacterium Innate Immune Response Defense Response To Gram-negative Bacterium B Cell Receptor Signaling Pathway Positive Regulation Of B Cell Activation	DNA Damage Checkpoint Signaling Protein Phosphorylation Cytoskeleton Organization Cell Cycle JNK Cascade Cell Death Cell Differentiation P38MAPK Cascade Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Stress-activated MAPK Cascade Regulation Of Cell Cycle Limb Development Cellular Response To Gamma Radiation Positive Regulation Of Mitotic DNA Damage Checkpoint
Pathways
Drugs			Dasatinib Fostamatinib
Diseases
GWAS		Systemic sclerosis ( 33069728)	Haemorrhoidal disease ( 33888516)
Interacting Genes		19 interacting genes: APP CD22 CD79A CEP72 GADD45A GSK3B HPR HSPA5 JCHAIN MAP3K20 MAPKAPK3 PTK2 SH3GL2 SMN1 TK1 UBQLN4 UFD1 VPREB1 VPREB3	32 interacting genes: CCDC69 CRMP1 DDAH2 EZH2 IGHM ITSN1 MAP2K4 MAP2K6 MAP2K7 MIDN MPP1 NEDD4L RBX1 RNF19A RPS6KA5 SMARCB1 SRPK2 TGFBR1 UNC119 VPS33B YWHAG YWHAZ ZFP1 ZFP2 ZNF33A ZNF35 ZNF567 ZNF593 ZNF660 ZNF71 ZNF746 ZNF775
Entrez ID		3507	51776
HPRD ID		00912	11791
Ensembl ID		ENSG00000211899	ENSG00000091436
Uniprot IDs			D4Q8H0 Q9NYL2
PDB IDs			5HES 5X5O 6JUT 6JUU
Enriched GO Terms of Interacting Partners?
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