IFNA2 and IFNAR2

Number of citations of the paper that reports this interaction (PubMedID 10339405)
34

Data Source:
HPRD (in vitro)

		IFNA2	IFNAR2
Description		interferon alpha 2	interferon alpha and beta receptor subunit 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Collagen-containing Extracellular Matrix	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Cytokine Activity Type I Interferon Receptor Binding Protein Binding	Cytokine Receptor Activity Type I Interferon Receptor Activity Protein Binding Protein Kinase Binding
	Biological Process	Adaptive Immune Response T Cell Activation Involved In Immune Response Natural Killer Cell Activation Involved In Immune Response Apoptotic Process Inflammatory Response Humoral Immune Response Cell Surface Receptor Signaling Pathway Cell-cell Signaling Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway B Cell Differentiation Negative Regulation Of Interleukin-13 Production Negative Regulation Of Interleukin-5 Production Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein B Cell Proliferation Positive Regulation Of Phosphorylation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Response To Exogenous DsRNA Negative Regulation Of T Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Viral Entry Into Host Cell Defense Response To Virus Negative Regulation Of T-helper 2 Cell Cytokine Production	Cell Surface Receptor Signaling Pathway Receptor Signaling Pathway Via JAK-STAT Response To Virus Cytokine-mediated Signaling Pathway Response To Interferon-alpha Response To Interferon-beta Defense Response To Virus Type I Interferon Signaling Pathway
Pathways		Interferon alpha/beta signaling Regulation of IFNA signaling Regulation of IFNA signaling TRAF6 mediated IRF7 activation Factors involved in megakaryocyte development and platelet production
Drugs		Sifalimumab	Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon alfa-2a, Recombinant Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon alfa-2b Human interferon omega-1 Nylidrin
Diseases
GWAS		Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494)	Attention deficit hyperactivity disorder ( 30563984) Cerebellum white matter volume ( 31530798) Crohn's disease ( 23128233) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Type 2 diabetes ( 30130595)
Interacting Genes		3 interacting genes: IFNAR1 IFNAR2 TIMMDC1	15 interacting genes: HLCS IFNA2 IFNA5 IFNA8 IFNAR1 IFNB1 JAK1 PPP1R3B PRKCB RACK1 STAT1 STAT2 STAT3 TYK2 USP18
Entrez ID		3440	3455
HPRD ID		00950	03850
Ensembl ID		ENSG00000188379	ENSG00000159110
Uniprot IDs		P01563	P48551 Q9BUA0
PDB IDs		1ITF 1RH2 2HIE 2HYM 2KZ1 2LAG 2LMS 3S9D 3SE3 4YPG 4Z5R	1N6U 1N6V 2HYM 2KZ1 2LAG 3S8W 3S9D 3SE3 3SE4
Enriched GO Terms of Interacting Partners?
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