IFNAR2 and USP18

Number of citations of the paper that reports this interaction (PubMedID 16710296)
186

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, in vitro)

		IFNAR2	USP18
Description		interferon alpha and beta receptor subunit 2	ubiquitin specific peptidase 18
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Nucleus Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Cytokine Receptor Activity Type I Interferon Receptor Activity Protein Binding Protein Kinase Binding	Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding ISG15-specific Protease Activity
	Biological Process	Cell Surface Receptor Signaling Pathway Receptor Signaling Pathway Via JAK-STAT Response To Virus Cytokine-mediated Signaling Pathway Response To Interferon-alpha Response To Interferon-beta Defense Response To Virus Type I Interferon Signaling Pathway	Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Regulation Of Inflammatory Response Negative Regulation Of Type I Interferon-mediated Signaling Pathway
Pathways			ISG15 antiviral mechanism Ub-specific processing proteases Regulation of IFNA signaling
Drugs		Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon alfa-2a, Recombinant Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon alfa-2b Human interferon omega-1 Nylidrin
Diseases
GWAS		Attention deficit hyperactivity disorder ( 30563984) Cerebellum white matter volume ( 31530798) Crohn's disease ( 23128233) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Type 2 diabetes ( 30130595)	Systemic lupus erythematosus ( 33272962)
Interacting Genes		15 interacting genes: HLCS IFNA2 IFNA5 IFNA8 IFNAR1 IFNB1 JAK1 PPP1R3B PRKCB RACK1 STAT1 STAT2 STAT3 TYK2 USP18	6 interacting genes: IFNAR2 ISG15 TMEM14A TRIM54 TWIST1 ZDHHC17
Entrez ID		3455	11274
HPRD ID		03850	06136
Ensembl ID		ENSG00000159110	ENSG00000184979
Uniprot IDs		P48551 Q9BUA0	Q9UMW8
PDB IDs		1N6U 1N6V 2HYM 2KZ1 2LAG 3S8W 3S9D 3SE3 3SE4
Enriched GO Terms of Interacting Partners?
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