HSPA6 and CYP4F12

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		HSPA6	CYP4F12
Description		heat shock protein family A (Hsp70) member 6	cytochrome P450 family 4 subfamily F member 12
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Centriole Cytosol Plasma Membrane Secretory Granule Lumen Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen	Cytoplasm Endoplasmic Reticulum Membrane Integral Component Of Membrane Apical Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding ATP Binding ATP Hydrolysis Activity Enzyme Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Protein Folding Chaperone Unfolded Protein Binding Misfolded Protein Binding	Monooxygenase Activity Iron Ion Binding Protein Binding Arachidonic Acid Monooxygenase Activity Arachidonic Acid Epoxygenase Activity Alkane 1-monooxygenase Activity Heme Binding Leukotriene-B4 20-monooxygenase Activity Aromatase Activity
	Biological Process	Response To Unfolded Protein Vesicle-mediated Transport Cellular Response To Heat Cellular Response To Unfolded Protein Protein Refolding Chaperone Cofactor-dependent Protein Refolding Cellular Heat Acclimation	Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Renal Water Homeostasis Pressure Natriuresis Fatty Acid Metabolic Process Xenobiotic Metabolic Process Arachidonic Acid Metabolic Process Epoxygenase P450 Pathway Leukotriene B4 Catabolic Process Vitamin E Metabolic Process Menaquinone Catabolic Process Phylloquinone Catabolic Process Vitamin K Catabolic Process Sodium Ion Homeostasis
Pathways		Regulation of HSF1-mediated heat shock response Neutrophil degranulation	Fatty acids Eicosanoids
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Birth weight ( 31043758) Blood protein levels ( 28240269) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Helicobacter pylori serologic status ( 23652523) Inflammatory bowel disease ( 28067908 23128233) Offspring birth weight ( 31043758) Ulcerative colitis ( 28067908 21297633)	Glioma ( 34319593) LDL cholesterol levels ( 32203549)
Interacting Genes		18 interacting genes: ADCK5 AHCYL1 BAG4 C22orf15 CISH COMMD6 CYP4F12 DNAJB4 FCGR2B FLNA KRT222 LGALS7 LGALS7B MPZ PPIB PRAP1 RPA1 TERF1	5 interacting genes: HSPA6 MEOX2 SLC44A2 SOD2 TIMMDC1
Entrez ID		3310	66002
HPRD ID		00775	07102
Ensembl ID		ENSG00000173110	ENSG00000186204
Uniprot IDs		A0A384NKX5 B3KSM6 P17066	Q9HCS2
PDB IDs		3FE1
Enriched GO Terms of Interacting Partners?
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