HSPA6 and MPZ

		HSPA6	MPZ
Description		heat shock protein family A (Hsp70) member 6	myelin protein zero
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GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Centriole Cytosol Plasma Membrane Secretory Granule Lumen Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen	Lysosome Rough Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Myelin Sheath Synapse
	Molecular Function	Protein Binding ATP Binding ATP Hydrolysis Activity Enzyme Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Protein Folding Chaperone Unfolded Protein Binding Misfolded Protein Binding	Structural Molecule Activity
	Biological Process	Response To Unfolded Protein Vesicle-mediated Transport Cellular Response To Heat Cellular Response To Unfolded Protein Protein Refolding Chaperone Cofactor-dependent Protein Refolding Cellular Heat Acclimation	Chemical Synaptic Transmission Myelination Negative Regulation Of Apoptotic Process Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell Aggregation
Pathways		Regulation of HSF1-mediated heat shock response Neutrophil degranulation	EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Birth weight ( 31043758) Blood protein levels ( 28240269) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Helicobacter pylori serologic status ( 23652523) Inflammatory bowel disease ( 28067908 23128233) Offspring birth weight ( 31043758) Ulcerative colitis ( 28067908 21297633)	Hip circumference adjusted for BMI ( 28552196) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		18 interacting genes: ADCK5 AHCYL1 BAG4 C22orf15 CISH COMMD6 CYP4F12 DNAJB4 FCGR2B FLNA KRT222 LGALS7 LGALS7B MPZ PPIB PRAP1 RPA1 TERF1	6 interacting genes: DEDD HSPA6 PINX1 PMP22 PSMB3 RGS4
Entrez ID		3310	4359
HPRD ID		00775	01159
Ensembl ID		ENSG00000173110	ENSG00000158887
Uniprot IDs		A0A384NKX5 B3KSM6 P17066	A0A5F9ZI26 P25189
PDB IDs		3FE1	1N2P 3OAI
Enriched GO Terms of Interacting Partners?
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