CYP4F12 and SOD2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		CYP4F12	SOD2
Description		cytochrome P450 family 4 subfamily F member 12	superoxide dismutase 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Integral Component Of Membrane Apical Plasma Membrane Intracellular Membrane-bounded Organelle	Mitochondrion Mitochondrial Matrix Mitochondrial Nucleoid Extracellular Exosome
	Molecular Function	Monooxygenase Activity Iron Ion Binding Protein Binding Arachidonic Acid Monooxygenase Activity Arachidonic Acid Epoxygenase Activity Alkane 1-monooxygenase Activity Heme Binding Leukotriene-B4 20-monooxygenase Activity Aromatase Activity	DNA Binding Superoxide Dismutase Activity Protein Binding Oxygen Binding Enzyme Binding Manganese Ion Binding Identical Protein Binding
	Biological Process	Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Renal Water Homeostasis Pressure Natriuresis Fatty Acid Metabolic Process Xenobiotic Metabolic Process Arachidonic Acid Metabolic Process Epoxygenase P450 Pathway Leukotriene B4 Catabolic Process Vitamin E Metabolic Process Menaquinone Catabolic Process Phylloquinone Catabolic Process Vitamin K Catabolic Process Sodium Ion Homeostasis	Response To Superoxide Age-dependent Response To Reactive Oxygen Species Response To Hypoxia Release Of Cytochrome C From Mitochondria Acetylcholine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Transcription By RNA Polymerase II Superoxide Metabolic Process Regulation Of Blood Pressure Negative Regulation Of Cell Population Proliferation Response To Radiation Response To Cold Response To Xenobiotic Stimulus Response To Manganese Ion Response To Zinc Ion Response To Selenium Ion Positive Regulation Of Hydrogen Peroxide Biosynthetic Process Response To Activity Removal Of Superoxide Radicals Positive Regulation Of Cell Migration Oxygen Homeostasis Response To Lipopolysaccharide Response To L-ascorbic Acid Response To Silicon Dioxide Response To Isolation Stress Response To Immobilization Stress Response To Hydrogen Peroxide Negative Regulation Of Neuron Apoptotic Process Response To Cadmium Ion Hydrogen Peroxide Biosynthetic Process Protein Homotetramerization Response To Electrical Stimulus Response To Magnetism Cellular Response To Ethanol Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Membrane Hyperpolarization Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching
Pathways		Fatty acids Eicosanoids	Transcriptional activation of mitochondrial biogenesis Detoxification of Reactive Oxygen Species Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs			Benzylsulfonic acid 3-Fluoro-L-tyrosine
Diseases
GWAS		Glioma ( 34319593) LDL cholesterol levels ( 32203549)	Age-related macular degeneration (geographic atrophy) ( 22705344) Erosive tooth wear (severe vs non-severe) ( 29898447) Lipoprotein (a) levels ( 26377243) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Polycystic ovary syndrome ( 32289280) Pulse pressure ( 27841878)
Interacting Genes		5 interacting genes: HSPA6 MEOX2 SLC44A2 SOD2 TIMMDC1	10 interacting genes: APP CEP70 CYP4F12 DRC3 GET4 HDHD2 KIAA1549 NOL12 RAB4A RPS3A
Entrez ID		66002	6648
HPRD ID		07102	00938
Ensembl ID		ENSG00000186204	ENSG00000112096
Uniprot IDs		Q9HCS2	A0A384NL29 G5E9P6 P04179 Q96AM7 Q9UG59
PDB IDs			1AP5 1AP6 1EM1 1JA8 1LUV 1LUW 1MSD 1N0J 1N0N 1PL4 1PM9 1QNM 1SZX 1VAR 1XDC 1XIL 1ZSP 1ZTE 1ZUQ 2ADP 2ADQ 2GDS 2P4K 2QKA 2QKC 3C3S 3C3T 5GXO 5T30 5VF9
Enriched GO Terms of Interacting Partners?
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