HSD17B3 and MLH3

Number of citations of the paper that reports this interaction (PubMedID 24412244)
2

Data Source:
BioGRID (two hybrid)

		HSD17B3	MLH3
Description		hydroxysteroid 17-beta dehydrogenase 3	mutL homolog 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Mismatch Repair Complex
	Molecular Function	Oxidoreductase Activity Testosterone Dehydrogenase [NAD(P)] Activity Testosterone 17-beta-dehydrogenase (NADP+) Activity 17-beta-hydroxysteroid Dehydrogenase (NADP+) Activity	Chromatin Binding Satellite DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Centromeric DNA Binding Mismatched DNA Binding
	Biological Process	Steroid Biosynthetic Process Androgen Biosynthetic Process Male Genitalia Development Testosterone Biosynthetic Process	Mismatch Repair Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Female Meiosis I Protein Localization
Pathways		Androgen biosynthesis Synthesis of very long-chain fatty acyl-CoAs	Meiotic recombination
Drugs		NADH
Diseases
GWAS		Cerebrospinal fluid AB1-42 levels ( 26252872) Glomerular filtration rate in chronic kidney disease ( 26420894) Letter-number span reordering ( 31596458)	Inflammatory bowel disease ( 23128233) Mood instability ( 29187730) Refractive error ( 32231278)
Interacting Genes		9 interacting genes: BRAF BUB1 CDH1 CTNNA1 DLC1 ERBB2 MCC MLH3 SMAD2	48 interacting genes: AKT1 ALDOB ANP32B AOPEP AR BAAT CCDC180 CDC14B CDK8 CTSV CYLC2 DVL1 EXO1 FANCC FBP1 FBP2 FRAT2 GALNT12 HEMGN HRAS HSD17B3 IGFBP3 LEF1 MAP2K1 MLH1 MSANTD3 MSH4 MSH5 NANS PCNA PPP2CB PPP3R2 RASA1 SEC61B SFRP2 SMAD1 STX17 TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRIM55 TRIM63 TSTD2 XPA ZDHHC17 ZNF510
Entrez ID		3293	27030
HPRD ID		05716	05094
Ensembl ID		ENSG00000130948	ENSG00000119684
Uniprot IDs		P37058 Q6FH62	Q2M1Z1 Q9UHC1
PDB IDs
Enriched GO Terms of Interacting Partners?
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