HNRNPC and BRIP1

Number of citations of the paper that reports this interaction (PubMedID 23585894)
30

Data Source:
BioGRID (unspecified method)

		HNRNPC	BRIP1
Description		heterogeneous nuclear ribonucleoprotein C	BRCA1 interacting helicase 1
Image
GO Annotations	Cellular Component	Chromatin Extracellular Region Nucleus Nucleoplasm Spliceosomal Complex Telomerase Holoenzyme Complex Cytosol Actin Cytoskeleton Membrane Protein-containing Complex Extracellular Exosome Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Cytoplasm Nuclear Membrane
	Molecular Function	RNA Binding MRNA 3'-UTR Binding Protein Binding Poly(U) RNA Binding Nucleosomal DNA Binding Identical Protein Binding Telomerase RNA Binding N6-methyladenosine-containing RNA Binding	DNA Binding DNA Helicase Activity Chromatin Binding RNA Helicase Activity Protein Binding ATP Binding ATP Hydrolysis Activity 5'-3' DNA Helicase Activity Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	MRNA Splicing, Via Spliceosome Osteoblast Differentiation Chromatin Remodeling RNA Splicing Negative Regulation Of Telomere Maintenance Via Telomerase 3'-UTR-mediated MRNA Stabilization	DNA Damage Checkpoint Signaling Nucleotide-excision Repair Double-strand Break Repair Regulation Of Transcription By RNA Polymerase II Spermatogonial Cell Division Spermatid Development Negative Regulation Of Cell Population Proliferation Response To Toxic Substance Negative Regulation Of Gene Expression Meiotic DNA Double-strand Break Processing Involved In Reciprocal Meiotic Recombination DNA Duplex Unwinding Chiasma Assembly Cellular Response To Vitamin Cellular Response To Hypoxia Seminiferous Tubule Development Cellular Response To Angiotensin Double-strand Break Repair Involved In Meiotic Recombination
Pathways		SUMOylation of RNA binding proteins mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle	Cytosolic iron-sulfur cluster assembly HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756 21738484) Height ( 31562340)	Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Ovarian cancer ( 21964575) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		60 interacting genes: AP1M1 BARD1 BRCA1 BRCA2 BRIP1 BTRC CCDC85B CDKN2A CSNK1A1 CSNK2A1 CSNK2A2 DHX9 DISC1 DLG4 EPS8 ERG ESR1 FAS FXR2 GRB2 HNRNPCL1 HNRNPCL2 IL7R KHDRBS3 KPNA2 KPNA3 KPNA4 KPNA5 KRAS LMO2 LMO3 MEOX2 NUFIP2 OGT PALB2 PAX6 PDGFB PHKB PIN1 PJA1 PRKDC PTBP2 RAD51 RALY RALYL RBM41 RBPMS2 SDCBP SF3B2 SMARCD1 SREK1 SRPK2 SUMO1 SUMO1P1 TRAF3 UBE2I YWHAE YWHAQ ZFYVE26 ZNF581	14 interacting genes: BLM BRCA1 CREBBP FANCD2 HDAC3 HNRNPC HPN HSD17B14 MRPS23 PATZ1 PECAM1 RPA1 SIRT1 TOPBP1
Entrez ID		3183	83990
HPRD ID		01243	05797
Ensembl ID		ENSG00000092199	ENSG00000136492
Uniprot IDs		P07910	Q9BX63
PDB IDs		1TXP 1WF2 2MXY 2MZ1 3LN4	1T15 1T29 3AL3
Enriched GO Terms of Interacting Partners?
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