BRIP1

Description		BRCA1 interacting helicase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Membrane
	Molecular Function	DNA Binding DNA Helicase Activity Chromatin Binding RNA Helicase Activity Protein Binding ATP Binding ATP Hydrolysis Activity 5'-3' DNA Helicase Activity Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	DNA Damage Checkpoint Signaling Nucleotide-excision Repair Double-strand Break Repair Regulation Of Transcription By RNA Polymerase II Spermatogonial Cell Division Spermatid Development Negative Regulation Of Cell Population Proliferation Response To Toxic Substance Negative Regulation Of Gene Expression Meiotic DNA Double-strand Break Processing Involved In Reciprocal Meiotic Recombination DNA Duplex Unwinding Chiasma Assembly Cellular Response To Vitamin Cellular Response To Hypoxia Seminiferous Tubule Development Cellular Response To Angiotensin Double-strand Break Repair Involved In Meiotic Recombination
Pathways		Cytosolic iron-sulfur cluster assembly HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Drugs
Diseases
GWAS		Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Ovarian cancer ( 21964575) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		14 interacting genes: BLM BRCA1 CREBBP FANCD2 HDAC3 HNRNPC HPN HSD17B14 MRPS23 PATZ1 PECAM1 RPA1 SIRT1 TOPBP1
Entrez ID		83990
HPRD ID		05797
Ensembl ID		ENSG00000136492
Uniprot IDs		Q9BX63
PDB IDs		1T15 1T29 3AL3
Enriched GO Terms of Interacting Partners?
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