GZMB and NEK9

		GZMB	NEK9
Description		granzyme B	NIMA related kinase 9
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GO Annotations	Cellular Component	Immunological Synapse Extracellular Region Nucleus Cytoplasm Mitochondrion Cytosol Membrane Intracellular Membrane-bounded Organelle Cytolytic Granule	Nucleus Centrosome Cytosol
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity	Protein Binding ATP Binding Protein Kinase Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Apoptotic Process Negative Regulation Of Translation Cytolysis Natural Killer Cell Mediated Cytotoxicity Proteolysis Involved In Cellular Protein Catabolic Process Pyroptosis Granzyme-mediated Programmed Cell Death Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	Protein Phosphorylation Cell Cycle Cell Division
Pathways		NOTCH2 intracellular domain regulates transcription Pyroptosis Activation, myristolyation of BID and translocation to mitochondria	Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation
Drugs			Fostamatinib
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Vitiligo ( 20410501 27723757)	Coronary artery disease ( 29212778) Feeling fed-up ( 29500382)
Interacting Genes		27 interacting genes: BID CASP3 CASP7 CASP8 CASP9 CD2AP CHRM3 DFFA GRIA3 IGF2R LMNA LMNB1 NEK9 PARP1 PRF1 PRKDC PTGES3 PTK2 RAB27A SERPINB9 SRGN TUBA1A UBE4A UBE4B XRCC4 XRCC5 XRCC6	21 interacting genes: BICD2 CSN2 GABARAP GZMB IFT43 JDP2 LIN52 MALL MAP1LC3B MBP NEK6 NEK7 NEK8 PALS1 RAN RARG RPS6KL1 SSRP1 SUPT16H TTN WDR33
Entrez ID		3002	91754
HPRD ID		00476	11386
Ensembl ID		ENSG00000100453	ENSG00000119638
Uniprot IDs		J3KQ52 P10144 Q67BC3 Q6XGZ4	A0A7I2V454 A0A7I2V5R1 Q6PKF2 Q8TD19
PDB IDs		1FQ3 1IAU	3ZKE 3ZKF
Enriched GO Terms of Interacting Partners?
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