NCAPH2 and FOLR1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		NCAPH2	FOLR1
Description		non-SMC condensin II complex subunit H2	folate receptor alpha
Image		No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome Condensin Complex Nucleus Nucleoplasm Membrane Cell Junction Intercellular Bridge	Golgi Membrane Nucleus Endosome Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Clathrin-coated Vesicle Anchored Component Of External Side Of Plasma Membrane Brush Border Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Extracellular Exosome
	Molecular Function	Chromatin Binding Protein Binding	Protein Binding Folic Acid Binding Signaling Receptor Activity Methotrexate Binding Folic Acid Receptor Activity
	Biological Process	Mitotic Chromosome Condensation Meiotic Chromosome Condensation T Cell Differentiation In Thymus Mitotic Sister Chromatid Separation Female Meiosis Chromosome Separation	Heart Looping Neural Crest Cell Migration Involved In Heart Formation Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Receptor-mediated Endocytosis Cell Adhesion Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Folic Acid Transport Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Axon Regeneration Sperm-egg Recognition Folic Acid Metabolic Process Regulation Of Canonical Wnt Signaling Pathway Pharyngeal Arch Artery Morphogenesis Anterior Neural Tube Closure Cellular Response To Folic Acid Folate Import Across Plasma Membrane
Pathways		Condensation of Prophase Chromosomes	COPII-mediated vesicle transport Cargo concentration in the ER COPI-mediated anterograde transport
Drugs			Folic acid Vintafolide Farletuzumab
Diseases
GWAS		B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Cerebrospinal fluid clusterin levels ( 26545630) Chronic lymphocytic leukemia ( 28165464) Mean corpuscular hemoglobin ( 32888494 20139978) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell traits ( 23222517) Serum metabolite levels ( 33031748)
Interacting Genes		25 interacting genes: ACTN2 ANKRD46 APOD C4orf3 CTXN3 EGLN3 EMD FDFT1 FOLR1 IGFBP5 LMO2 MAL ODAD4 PRPF31 SNRPC SUMO2 TMEM120B TMEM14C TMEM86A TRAF2 TTC32 TUBB UBIAD1 USHBP1 VAMP5	8 interacting genes: CUL3 INTS4 IRAK3 LTB4R2 LYN NCAPH2 PDE2A SLC35F6
Entrez ID		29781	2348
HPRD ID		11783	00638
Ensembl ID		ENSG00000025770	ENSG00000110195
Uniprot IDs		Q6IBW4	A0A024R5H1 P15328
PDB IDs			4KM6 4KM7 4KMX 4LRH 5IZQ
Enriched GO Terms of Interacting Partners?
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