HIPK2 and SIRT1

Number of citations of the paper that reports this interaction (PubMedID 26113041)
23

Data Source:
BioGRID (enzymatic study)

		HIPK2	SIRT1
Description		homeodomain interacting protein kinase 2	sirtuin 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Body PML Body RNA Polymerase II Transcription Regulator Complex	Chromatin Euchromatin Heterochromatin Fibrillar Center Nucleus Nuclear Envelope Nuclear Inner Membrane Nucleoplasm Chromatin Silencing Complex Nucleolus Cytoplasm Mitochondrion Cytosol PML Body RDNA Heterochromatin
	Molecular Function	Transcription Coactivator Activity Transcription Corepressor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding SMAD Binding Virion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein Serine Kinase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding P53 Binding Transcription Coactivator Activity Transcription Corepressor Activity NAD+ ADP-ribosyltransferase Activity Histone Deacetylase Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Nuclear Receptor Binding NAD-dependent Histone Deacetylase Activity Deacetylase Activity Enzyme Binding Protein Deacetylase Activity NAD-dependent Protein Deacetylase Activity Histone Binding Identical Protein Binding HLH Domain Binding BHLH Transcription Factor Binding Metal Ion Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) Mitogen-activated Protein Kinase Binding NAD+ Binding Protein-propionyllysine Depropionylase Activity Keratin Filament Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Eye Development Positive Regulation Of Protein Phosphorylation Protein Phosphorylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Transforming Growth Factor Beta Receptor Signaling Pathway Smoothened Signaling Pathway Adult Walking Behavior Positive Regulation Of Cell Population Proliferation Anterior/posterior Pattern Specification Retina Layer Formation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Neuron Differentiation Erythrocyte Differentiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway PML Body Organization Positive Regulation Of Protein Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of DNA Binding Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Embryonic Camera-type Eye Morphogenesis Voluntary Musculoskeletal Movement Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cell Cycle Embryonic Retina Morphogenesis In Camera-type Eye Lens Induction In Camera-type Eye SMAD Protein Signal Transduction Iris Morphogenesis Cellular Response To Hypoxia Intrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process	Single Strand Break Repair Negative Regulation Of Transcription By RNA Polymerase II RDNA Heterochromatin Assembly Pyrimidine Dimer Repair By Nucleotide-excision Repair DNA Synthesis Involved In DNA Repair Angiogenesis Ovulation From Ovarian Follicle Cellular Glucose Homeostasis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Adaptive Immune Response Chromatin Organization DNA Methylation-dependent Heterochromatin Assembly Protein ADP-ribosylation Protein Deacetylation Triglyceride Mobilization Cellular Response To DNA Damage Stimulus Response To Oxidative Stress Transforming Growth Factor Beta Receptor Signaling Pathway Spermatogenesis Regulation Of Mitotic Cell Cycle Muscle Organ Development Cell Aging Positive Regulation Of Cell Population Proliferation Cellular Response To Starvation Negative Regulation Of Gene Expression Regulation Of Centrosome Duplication Positive Regulation Of Cholesterol Efflux Regulation Of Lipid Storage Regulation Of Glucose Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Macroautophagy Protein Ubiquitination Histone Deacetylation Peptidyl-lysine Acetylation Macrophage Differentiation Negative Regulation Of Cell Growth Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Prostaglandin Biosynthetic Process Heterochromatin Assembly Protein Destabilization Negative Regulation Of TOR Signaling Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Insulin Circadian Regulation Of Gene Expression Leptin-mediated Signaling Pathway Regulation Of Smooth Muscle Cell Apoptotic Process Peptidyl-lysine Deacetylation Cellular Triglyceride Homeostasis Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Cell Population Proliferation Negative Regulation Of Phosphorylation Response To Hydrogen Peroxide Behavioral Response To Starvation Cholesterol Homeostasis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Blood Vessel Endothelial Cell Migration Response To Leptin Positive Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Gluconeogenesis Positive Regulation Of DNA Repair Positive Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Insulin Receptor Signaling Pathway White Fat Cell Differentiation Negative Regulation Of Helicase Activity Positive Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Histone H3-K9 Methylation Negative Regulation Of Protein Kinase B Signaling Fatty Acid Homeostasis Negative Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Macrophage Cytokine Production Histone H3-K9 Modification Cellular Response To Hydrogen Peroxide Regulation Of Bile Acid Biosynthetic Process UV-damage Excision Repair Histone H3 Deacetylation Cellular Response To Tumor Necrosis Factor Negative Regulation Of Histone H3-K14 Acetylation Cellular Response To Hypoxia Cellular Response To Ionizing Radiation Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Brown Fat Cell Differentiation Stress-induced Premature Senescence Protein Depropionylation Regulation Of Cellular Response To Heat Negative Regulation Of Histone H3-K9 Trimethylation Negative Regulation Of Neuron Death Negative Regulation Of Protein Acetylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Adipose Tissue Development Histone H3-K9 Deacetylation Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Macrophage Apoptotic Process Negative Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of CAMP-dependent Protein Kinase Activity Negative Regulation Of Histone H4-K16 Acetylation Negative Regulation Of Cellular Response To Testosterone Stimulus Negative Regulation Of Peptidyl-lysine Acetylation Negative Regulation Of Cellular Senescence Positive Regulation Of Cellular Senescence
Pathways		YAP1- and WWTR1 (TAZ)-stimulated gene expression SUMOylation of transcription cofactors Physiological factors Regulation of TP53 Activity through Phosphorylation RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MECP2 expression and activity	Regulation of HSF1-mediated heat shock response Circadian Clock SIRT1 negatively regulates rRNA expression SIRT1 negatively regulates rRNA expression Regulation of FOXO transcriptional activity by acetylation Regulation of FOXO transcriptional activity by acetylation Heme signaling
Drugs		Fostamatinib	Resveratrol Selisistat Cambinol
Diseases
GWAS		Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Systolic blood pressure ( 28135244)	Atrial fibrillation ( 30061737) Chronotype ( 30696823) Diverticular disease ( 30177863) Molybdenum levels ( 26025379) Pulse pressure ( 30224653)
Interacting Genes		54 interacting genes: AATF ABL1 BTRC CBX3 CHMP4B CREBBP CUL1 CXCL1 DAXX DDX39A DDX39B FBXW7 H2BC21 HMGA1 KAT2B MAP3K7 MBP MDM2 MECP2 MKNK1 MYB MYBL1 NKX2-1 NKX2-5 NKX3-1 NLK NTRK1 PARP1 PAX6 PML PTCH1 RANBP9 RUNX1 SCAP SENP1 SIAH1 SIAH2 SIRT1 SKI SMAD1 SMAD2 SMAD3 SP100 SUMO1 SUMO2 SUMO3 TP53 TP53INP1 TP63 TP73 TRADD UBE2I WSB1 ZBTB4	65 interacting genes: AFP AKT1 AR ARNTL BAZ1B BCL11A BHLHE41 BRIP1 CDK6 CENATAC CHFR CLOCK CSNK2B CTTN E2F1 EP300 ESRRA EZH2 FOS FOXM1 FOXO1 FOXO3 GAPDH H1-5 H3C1 HES1 HEY2 HIC1 HIPK2 HNF4A HOXB9 MAPK8 MPHOSPH8 MYCN NBN NDN NMNAT1 NR1H2 NR1H3 NR1H4 PARP1 PML PPARA PPARG PPARGC1A PRMT1 PSME3 RARA RELA RICTOR RRP8 SATB1 SETD7 SMAD7 SMURF2 SNW1 STK11 STK4 SUMO2 TP53 TP73 TRIM28 UBE2I USP22 VDR
Entrez ID		28996	23411
HPRD ID		06039	08381
Ensembl ID		ENSG00000064393	ENSG00000096717
Uniprot IDs		Q9H2X6	A0A024QZQ1 A8K128 B0QZ35 E9PC49 Q96EB6
PDB IDs		6P5S 7NCF	4I5I 4IF6 4IG9 4KXQ 4ZZH 4ZZI 4ZZJ 5BTR
Enriched GO Terms of Interacting Partners?
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