SIRT1 and PPARGC1A

  • Number of citations of the paper that reports this interaction (PubMedID 15744310)
  • 1197
  • Data Source:
  • BioGRID (enzymatic study)
  • HPRD (in vitro, in vivo)

SIRT1

PPARGC1A

Description sirtuin 1 PPARG coactivator 1 alpha
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Aspartate aminotransferase levels ( 33547301)
  • Coffee consumption ( 31046077)
  • Cognitive decline rate in late mild cognitive impairment ( 26252872)
  • Corneal astigmatism ( 29422769)
  • Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
  • Essential tremor ( 27797806)
  • Estimated glomerular filtration rate ( 31152163 31015462)
  • Hematocrit ( 32888494)
  • Hemoglobin ( 32888494)
  • Intralaminar thalamic nuclei volume ( 34006833)
  • Lead levels ( 26025379)
  • Molar-incisor hypomineralization ( 23918034)
  • PR interval ( 32439900)
  • Refractive error ( 32231278)
  • Resting heart rate ( 27798624)
  • Rosacea symptom severity ( 29771307)
  • Schizophrenia ( 30285260)
  • Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306)
  • Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes 65 interacting genes: AFP AKT1 AR ARNTL BAZ1B BCL11A BHLHE41 BRIP1 CDK6 CENATAC CHFR CLOCK CSNK2B CTTN E2F1 EP300 ESRRA EZH2 FOS FOXM1 FOXO1 FOXO3 GAPDH H1-5 H3C1 HES1 HEY2 HIC1 HIPK2 HNF4A HOXB9 MAPK8 MPHOSPH8 MYCN NBN NDN NMNAT1 NR1H2 NR1H3 NR1H4 PARP1 PML PPARA PPARG PPARGC1A PRMT1 PSME3 RARA RELA RICTOR RRP8 SATB1 SETD7 SMAD7 SMURF2 SNW1 STK11 STK4 SUMO2 TP53 TP73 TRIM28 UBE2I USP22 VDR 44 interacting genes: CAPNS1 CDK6 CREBBP ESR1 ESR2 ESRRA ESRRG FBXW7 GSK3B HCFC1 HNF4A LRPPRC MAPK14 MED1 MED12 MED14 MED17 MYBBP1A NCL NCOA1 NCOA6 NDN NR1H4 NR1I2 NR1I3 NR3C1 NRF1 PCDH7 PPARA PPARD PPARG RARB RXRA SIRT1 SKP1 SRSF4 SRSF5 SRSF6 THRB TP53 UBC UBE2I USF1 USF2
Entrez ID 23411 10891
HPRD ID 08381 05155
Ensembl ID ENSG00000096717 ENSG00000109819
Uniprot IDs A0A024QZQ1 A8K128 B0QZ35 E9PC49 Q96EB6 A0A024R9Q9 Q9UBK2
PDB IDs 4I5I 4IF6 4IG9 4KXQ 4ZZH 4ZZI 4ZZJ 5BTR 1XB7 3B1M 3CS8 3D24 3U9Q 3V9T 3V9V 4QJR 4QK4 5Q0I 5TWO 5UNJ 5Z5S 5Z6S 6AD9 6FZF 6FZP 6IZM 6IZN 6K0T 6KXX 6KXY 6LN4 6MS7 6NWK 6NWL 6W9K 6W9L
Enriched GO Terms of Interacting Partners?
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