ASTE1 and NPHP3

		ASTE1	NPHP3
Description		asteroid homolog 1	nephrocystin 3
Image		No pdb structure
GO Annotations	Cellular Component		Extracellular Region Cytosol Cilium
	Molecular Function	Nuclease Activity Protein Binding	Protein Binding
	Biological Process	Nucleic Acid Phosphodiester Bond Hydrolysis	Kidney Development Heart Looping Atrial Septum Development Determination Of Left/right Symmetry Wnt Signaling Pathway Lung Development Determination Of Pancreatic Left/right Asymmetry Photoreceptor Cell Maintenance Maintenance Of Animal Organ Identity Convergent Extension Involved In Gastrulation Cilium Assembly Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Kidney Morphogenesis Determination Of Intestine Left/right Asymmetry Determination Of Stomach Left/right Asymmetry Determination Of Liver Left/right Asymmetry Ureter Development Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Planar Cell Polarity Pathway Involved In Neural Tube Closure
Pathways			Trafficking of myristoylated proteins to the cilium
Drugs
Diseases
GWAS		Phenylephrine infusion rate during anesthesia ( 31455332) Restless legs syndrome ( 29029846)	Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Menarche (age at onset) ( 27182965 21102462) Serum alkaline phosphatase levels ( 33547301) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		2 interacting genes: NPHP3 XRCC4	18 interacting genes: ANAPC13 ASTE1 ATXN1 CCDC50 CDV3 COL7A1 DDX3Y DNAJC13 DPP7 DYSF EPC1 NAA50 NPHP1 PARP14 PIK3R4 PPP2R3A RAB6B TOPBP1
Entrez ID		28990	27031
HPRD ID		11038	06417
Ensembl ID		ENSG00000034533	ENSG00000113971
Uniprot IDs		D6RG30 Q2TB18	Q7Z494
PDB IDs			5L7K
Enriched GO Terms of Interacting Partners?
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