GNAL and DOCK2

		GNAL	DOCK2
Description		G protein subunit alpha L	dedicator of cytokinesis 2
Image		No pdb structure
GO Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Extracellular Exosome	Extracellular Region Cytosol Cytoskeleton Membrane Specific Granule Lumen Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding T Cell Receptor Binding
	Biological Process	Signal Transduction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Sensory Perception Of Chemical Stimulus	Membrane Raft Polarization Establishment Of T Cell Polarity Immunological Synapse Formation Myeloid Dendritic Cell Activation Involved In Immune Response Chemotaxis Small GTPase Mediated Signal Transduction Actin Cytoskeleton Organization Macropinocytosis Positive Thymic T Cell Selection Negative Thymic T Cell Selection Alpha-beta T Cell Proliferation Positive Regulation Of Phagocytosis Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Olfactory Signaling Pathway	Nef and signal transduction Neutrophil degranulation RHOA GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 27089180) Alcohol dependence ( 26365420) Metabolite levels ( 23823483) QT interval (drug interaction) ( 23459443) Sensation seeking ( 30718321) Tandem gait ( 26219847) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Acne (severe) ( 24927181) Body mass index and waist-hip ratio (pleiotropy) ( 29868124) Coronary artery aneurysm in Kawasaki disease ( 33772158) Placental abruption ( 29884306) Pneumococcal bacteremia ( 27236921) Prostate cancer ( 29892016) Protein quantitative trait loci ( 18464913)
Interacting Genes		6 interacting genes: DOCK2 KCNH3 MIF TAF3 USP8 WASL	49 interacting genes: CALCOCO2 CARD10 CCNDBP1 CD247 CRKL CYSRT1 ELMO1 GNAL GOLGA6L9 HNRNPK HOXA1 KHDRBS1 KHDRBS2 KHDRBS3 KRT31 KRT34 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP17-1 KRTAP3-1 KRTAP3-3 KRTAP4-2 KRTAP5-7 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 MDFI MTDH MTUS2 NBPF19 NOTCH2NLA PAK2 PCSK5 PLEKHF2 PLSCR1 RAC1 RAC2 TENM4 TGM1 TRIM23 VAV1
Entrez ID		2774	1794
HPRD ID		00758	09121
Ensembl ID		ENSG00000141404	ENSG00000134516
Uniprot IDs		A8K1Y9 P38405	Q5XG91 Q92608
PDB IDs			2RQR 2YIN 3A98 3B13 6TGB 6TGC
Enriched GO Terms of Interacting Partners?
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