AGO2 and BTRC

Number of citations of the paper that reports this interaction (PubMedID 19647520)
87

Data Source:
BioGRID (unspecified method)

		AGO2	BTRC
Description		argonaute RISC catalytic component 2	beta-transducin repeat containing E3 ubiquitin protein ligase
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GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Cytosol Polysome MRNA Cap Binding Complex Membrane RISC Complex Dendrite Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome RISC-loading Complex Ribonucleoprotein Complex	Nucleoplasm Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	RNA 7-methylguanosine Cap Binding RNA Polymerase II Complex Binding Core Promoter Sequence-specific DNA Binding RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Translation Initiation Factor Activity Endoribonuclease Activity Protein Binding Protein C-terminus Binding SiRNA Binding MiRNA Binding Metal Ion Binding Endoribonuclease Activity, Cleaving SiRNA-paired MRNA Endoribonuclease Activity, Cleaving MiRNA-paired MRNA MRNA Cap Binding	Ubiquitin-protein Transferase Activity Protein Binding Beta-catenin Binding Ligase Activity Protein Phosphorylated Amino Acid Binding Protein Dimerization Activity Ubiquitin Protein Ligase Activity Ubiquitin Ligase-substrate Adaptor Activity Ubiquitin Ligase Activator Activity
	Biological Process	Translation Translational Initiation Post-embryonic Development RNA Secondary Structure Unwinding MiRNA Metabolic Process Gene Silencing By RNA Pre-miRNA Processing SiRNA Loading Onto RISC Involved In RNA Interference Post-transcriptional Gene Silencing By RNA Production Of MiRNAs Involved In Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation MRNA Cleavage Involved In Gene Silencing By MiRNA MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Translational Initiation Positive Regulation Of Translation, NcRNA-mediated Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening RNA Phosphodiester Bond Hydrolysis, Endonucleolytic MRNA Cleavage Involved In Gene Silencing By SiRNA Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Trophoblast Cell Migration Positive Regulation Of MiRNA Mediated Inhibition Of Translation	Protein Polyubiquitination Protein Dephosphorylation Ubiquitin-dependent Protein Catabolic Process Signal Transduction Wnt Signaling Pathway Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Mammary Gland Epithelial Cell Proliferation Regulation Of Circadian Rhythm Positive Regulation Of Circadian Rhythm Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Proteolysis Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Rhythmic Process Regulation Of Cell Cycle Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Canonical Wnt Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Protein K48-linked Ubiquitination Cellular Response To Organic Cyclic Compound Positive Regulation Of Ubiquitin Protein Ligase Activity
Pathways		Pre-NOTCH Transcription and Translation MicroRNA (miRNA) biogenesis Ca2+ pathway Small interfering RNA (siRNA) biogenesis Post-transcriptional silencing by small RNAs Transcriptional regulation by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Regulation of RUNX1 Expression and Activity Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Activation of NF-kappaB in B cells Prolactin receptor signaling SCF-beta-TrCP mediated degradation of Emi1 Vpu mediated degradation of CD4 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Deactivation of the beta-catenin transactivating complex Circadian Clock Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Neddylation Interleukin-1 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Multisite chronic pain ( 33830993) Neurociticism ( 29500382) Type 1 diabetes ( 34012112)	Diastolic blood pressure ( 30224653) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) Red blood cell count ( 29403010) Red cell distribution width ( 32888494) Smoking initiation ( 33082346) Smoking status (ever vs never smokers) ( 30643258) Walking pace ( 33128006)
Interacting Genes		27 interacting genes: AGO1 BTRC DCP1A DCP2 DDX20 DHX58 DICER1 GEMIN4 ITCH KAT5 LINC00467 MAPKAPK2 MIR19A MIRLET7B MIRLET7I NSD2 PFKP POLA2 PRKRA RAD51 TARBP2 TBK1 TBKBP1 TRIM55 TRIM63 UBAP2L UBC	86 interacting genes: AGO2 AMER1 ATF4 AXIN1 AXIN2 BORA CCND1 CCNE1 CDC25A CDC34 CDK1 CENPW CHPF CHUK CP CTNNB1 CUL1 DBN1 DEPTOR DLGAP5 DPCD E2F1 FBXW11 FBXW2 FOXO3 FZR1 GHR GLI2 GLI3 GSK3B HIPK2 HNRNPC HNRNPK HNRNPU ICE1 IL10RA JUP KDR KMT5A LINC00511 LPCAT1 MCL1 MDM2 MYB MYC NFE2 NFE2L2 NFKB1 NFKB2 NFKBIA NFKBIB NHSL2 PAQR3 PCDH8 PDCD4 PER2 PLK4 PRDX1 PSMA3 PSMD4 RASSF5 RCAN1 RELA RNF7 SKP1 SLC7A11-AS1 SMAD3 SMAD4 SMURF1 SMURF2 SUFU TACC1 TAFAZZIN TIAM1 TP63 TRIB2 TRIM36 TRIM9 TSPAN15 UBC UBE2D2 UBE2R2 UBQLN2 WEE1 XRCC1 ZC3H12A
Entrez ID		27161	8945
HPRD ID		06943	04596
Ensembl ID		ENSG00000123908	ENSG00000166167
Uniprot IDs		Q9UKV8	A0A0S2Z4P6 B2R8L3 B7Z3H4 Q68DS0 Q9Y297
PDB IDs		3LUC 3LUD 3LUG 3LUH 3LUJ 3LUK 3QX8 3QX9 4F3T 4OLA 4OLB 4W5N 4W5O 4W5Q 4W5R 4W5T 4Z4C 4Z4D 4Z4E 4Z4F 4Z4G 4Z4H 4Z4I 5JS1 5JS2 5KI6 5T7B 5WEA 6CBD 6MDZ 6MFN 6MFR 6N4O 6NIT 6RA4 7C6B 7D7U	1P22 2P64 6M90 6M91 6M92 6M93 6M94 6TTU
Enriched GO Terms of Interacting Partners?
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