AGO2 and TBKBP1

Number of citations of the paper that reports this interaction (PubMedID 21903422)
143

Data Source:
BioGRID (affinity chromatography technology, pull down)

		AGO2	TBKBP1
Description		argonaute RISC catalytic component 2	TBK1 binding protein 1
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Cytosol Polysome MRNA Cap Binding Complex Membrane RISC Complex Dendrite Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome RISC-loading Complex Ribonucleoprotein Complex	Cytoplasm
	Molecular Function	RNA 7-methylguanosine Cap Binding RNA Polymerase II Complex Binding Core Promoter Sequence-specific DNA Binding RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Translation Initiation Factor Activity Endoribonuclease Activity Protein Binding Protein C-terminus Binding SiRNA Binding MiRNA Binding Metal Ion Binding Endoribonuclease Activity, Cleaving SiRNA-paired MRNA Endoribonuclease Activity, Cleaving MiRNA-paired MRNA MRNA Cap Binding	Protein Binding Metal Ion Binding
	Biological Process	Translation Translational Initiation Post-embryonic Development RNA Secondary Structure Unwinding MiRNA Metabolic Process Gene Silencing By RNA Pre-miRNA Processing SiRNA Loading Onto RISC Involved In RNA Interference Post-transcriptional Gene Silencing By RNA Production Of MiRNAs Involved In Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation MRNA Cleavage Involved In Gene Silencing By MiRNA MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Translational Initiation Positive Regulation Of Translation, NcRNA-mediated Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening RNA Phosphodiester Bond Hydrolysis, Endonucleolytic MRNA Cleavage Involved In Gene Silencing By SiRNA Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Trophoblast Cell Migration Positive Regulation Of MiRNA Mediated Inhibition Of Translation	I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response
Pathways		Pre-NOTCH Transcription and Translation MicroRNA (miRNA) biogenesis Ca2+ pathway Small interfering RNA (siRNA) biogenesis Post-transcriptional silencing by small RNAs Transcriptional regulation by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Regulation of RUNX1 Expression and Activity Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Multisite chronic pain ( 33830993) Neurociticism ( 29500382) Type 1 diabetes ( 34012112)	Ankylosing spondylitis ( 23749187 21743469) Asthma ( 31619474) Asthma (childhood onset) ( 31036433) Body mass index ( 26426971 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically inactive individuals ( 28448500) Human herpesÂ virusÂ 7 U14Â antibodyÂ levels ( 33204752) Mean corpuscular hemoglobin ( 32888494) Multiple sclerosis ( 22190364) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		27 interacting genes: AGO1 BTRC DCP1A DCP2 DDX20 DHX58 DICER1 GEMIN4 ITCH KAT5 LINC00467 MAPKAPK2 MIR19A MIRLET7B MIRLET7I NSD2 PFKP POLA2 PRKRA RAD51 TARBP2 TBK1 TBKBP1 TRIM55 TRIM63 UBAP2L UBC	6 interacting genes: AGO2 APBA3 CALCOCO2 CBX1 RB1CC1 SKAP1
Entrez ID		27161	9755
HPRD ID		06943	12239
Ensembl ID		ENSG00000123908	ENSG00000198933
Uniprot IDs		Q9UKV8	A7MCY6
PDB IDs		3LUC 3LUD 3LUG 3LUH 3LUJ 3LUK 3QX8 3QX9 4F3T 4OLA 4OLB 4W5N 4W5O 4W5Q 4W5R 4W5T 4Z4C 4Z4D 4Z4E 4Z4F 4Z4G 4Z4H 4Z4I 5JS1 5JS2 5KI6 5T7B 5WEA 6CBD 6MDZ 6MFN 6MFR 6N4O 6NIT 6RA4 7C6B 7D7U
Enriched GO Terms of Interacting Partners?
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