BTRC and FBXW2

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology)

		BTRC	FBXW2
Description		beta-transducin repeat containing E3 ubiquitin protein ligase	F-box and WD repeat domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol SCF Ubiquitin Ligase Complex	Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Beta-catenin Binding Ligase Activity Protein Phosphorylated Amino Acid Binding Protein Dimerization Activity Ubiquitin Protein Ligase Activity Ubiquitin Ligase-substrate Adaptor Activity Ubiquitin Ligase Activator Activity	Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	Protein Polyubiquitination Protein Dephosphorylation Ubiquitin-dependent Protein Catabolic Process Signal Transduction Wnt Signaling Pathway Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Mammary Gland Epithelial Cell Proliferation Regulation Of Circadian Rhythm Positive Regulation Of Circadian Rhythm Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Proteolysis Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Rhythmic Process Regulation Of Cell Cycle Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Canonical Wnt Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Protein K48-linked Ubiquitination Cellular Response To Organic Cyclic Compound Positive Regulation Of Ubiquitin Protein Ligase Activity	Cellular Protein Modification Process Proteolysis Protein Ubiquitination
Pathways		Activation of NF-kappaB in B cells Prolactin receptor signaling SCF-beta-TrCP mediated degradation of Emi1 Vpu mediated degradation of CD4 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Deactivation of the beta-catenin transactivating complex Circadian Clock Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Neddylation Interleukin-1 signaling Antigen processing: Ubiquitination & Proteasome degradation	Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Diastolic blood pressure ( 30224653) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) Red blood cell count ( 29403010) Red cell distribution width ( 32888494) Smoking initiation ( 33082346) Smoking status (ever vs never smokers) ( 30643258) Walking pace ( 33128006)	Hip circumference adjusted for BMI ( 25673412)
Interacting Genes		86 interacting genes: AGO2 AMER1 ATF4 AXIN1 AXIN2 BORA CCND1 CCNE1 CDC25A CDC34 CDK1 CENPW CHPF CHUK CP CTNNB1 CUL1 DBN1 DEPTOR DLGAP5 DPCD E2F1 FBXW11 FBXW2 FOXO3 FZR1 GHR GLI2 GLI3 GSK3B HIPK2 HNRNPC HNRNPK HNRNPU ICE1 IL10RA JUP KDR KMT5A LINC00511 LPCAT1 MCL1 MDM2 MYB MYC NFE2 NFE2L2 NFKB1 NFKB2 NFKBIA NFKBIB NHSL2 PAQR3 PCDH8 PDCD4 PER2 PLK4 PRDX1 PSMA3 PSMD4 RASSF5 RCAN1 RELA RNF7 SKP1 SLC7A11-AS1 SMAD3 SMAD4 SMURF1 SMURF2 SUFU TACC1 TAFAZZIN TIAM1 TP63 TRIB2 TRIM36 TRIM9 TSPAN15 UBC UBE2D2 UBE2R2 UBQLN2 WEE1 XRCC1 ZC3H12A	11 interacting genes: BTRC CDC34 CLVS2 CTNNB1 CUL1 EXOSC2 MSX2 MYB SKP1 TRIM54 UBE2D2
Entrez ID		8945	26190
HPRD ID		04596	09950
Ensembl ID		ENSG00000166167	ENSG00000119402
Uniprot IDs		A0A0S2Z4P6 B2R8L3 B7Z3H4 Q68DS0 Q9Y297	B4DT60 Q9UKT8
PDB IDs		1P22 2P64 6M90 6M91 6M92 6M93 6M94 6TTU
Enriched GO Terms of Interacting Partners?
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