SENP8 and USP28

Number of citations of the paper that reports this interaction (PubMedID 22626734)
6

Data Source:
BioGRID (enzymatic study)

		SENP8	USP28
Description		SUMO peptidase family member, NEDD8 specific	ubiquitin specific peptidase 28
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GO Annotations	Cellular Component	Cytosol	Nucleus Nucleoplasm Cytosol Nuclear Body Protein-containing Complex
	Molecular Function	Protein Binding NEDD8-specific Protease Activity	Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding
	Biological Process	Protein Deubiquitination Post-translational Protein Modification	DNA Damage Checkpoint Signaling DNA Repair Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Ras Protein Signal Transduction Cell Population Proliferation Response To Ionizing Radiation Protein Deubiquitination Regulation Of Protein Stability Cellular Response To UV Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Pathways		UCH proteinases Neddylation	Ub-specific processing proteases
Drugs
Diseases
GWAS		Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Metabolite levels (HVA/MHPG ratio) ( 23319000)	Alcohol consumption (drinks per week) ( 30643258) Low density lipoprotein cholesterol levels ( 32154731) PR interval ( 32439900)
Interacting Genes		15 interacting genes: CHN2 COPS2 CUL1 CUL2 CUL4A GPS1 HSPA4 NEDD8 PLA2G2A SMURF1 TERF1 UBE2M USP15 USP21 USP28	40 interacting genes: ATXN3L BAP1 CLSPN ESPL1 HIF1A JOSD1 KDM1A MAP3K1 MDC1 MTNR1A NSMCE2 OTUB1 OTUB2 PJA1 PLA2G2A PRKD1 RFFL SENP1 SENP8 STAM STAMBP SUMO2 TP53 TP53BP1 TRIM55 TRIM63 UBC UCHL1 UCHL3 UCHL5 USP14 USP15 USP20 USP21 USP33 USP4 USP5 USP51 USP7 USP8
Entrez ID		123228	57646
HPRD ID		09784	15632
Ensembl ID		ENSG00000166192	ENSG00000048028
Uniprot IDs		A8K8D3 Q96LD8	B4E3L3 Q96RU2
PDB IDs		1XT9 2BKQ 2BKR	2LVA 2MUU 6H4H 6H4I 6HEH 6HEI 6HEJ 6HEK
Enriched GO Terms of Interacting Partners?
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