BMPR1B and KLHL1

Number of citations of the paper that reports this interaction (PubMedID 15761153)
269

Data Source:
HPRD (in vivo)

		BMPR1B	KLHL1
Description		bone morphogenetic protein receptor type 1B	kelch like family member 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Neuronal Cell Body Receptor Complex HFE-transferrin Receptor Complex	Cytoplasm Cytoskeleton Dendrite Neuronal Cell Body
	Molecular Function	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Phosphatase Activator Activity BMP Binding Protein Serine/threonine Kinase Activator Activity SMAD Binding Metal Ion Binding BMP Receptor Activity Transcription Regulator Activator Activity	Actin Binding Protein Binding
	Biological Process	Skeletal System Development Cartilage Condensation Ovarian Cumulus Expansion Osteoblast Differentiation Eye Development Chondrocyte Development Protein Phosphorylation Inflammatory Response Dorsal/ventral Pattern Formation Proteoglycan Biosynthetic Process Positive Regulation Of Bone Mineralization BMP Signaling Pathway Retinal Ganglion Cell Axon Guidance Positive Regulation Of Chondrocyte Differentiation Limb Morphogenesis Ovulation Cycle Positive Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Retina Development In Camera-type Eye Endochondral Bone Morphogenesis Positive Regulation Of Cartilage Development Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Chondrocyte Proliferation	Adult Walking Behavior Dendrite Development Cerebellar Purkinje Cell Layer Development Actin Cytoskeleton Organization
Pathways		Signaling by BMP
Drugs		Fostamatinib
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Attention deficit hyperactivity disorder ( 20732626) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778 33020668) Diverticular disease ( 30177863) Haemorrhoidal disease ( 33888516) Heel bone mineral density ( 30598549) Hen's egg allergy ( 29051540) Maximum stenosis ( 32469969) Opioid dependence (time to event) ( 34124712) Polycystic ovary syndrome (reproductive subtype) ( 32574161) Prepulse inhibition of the startle response ( 31596458) Schizophrenia ( 30470734) Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969) Systolic blood pressure ( 30224653 30578418) Waist-hip ratio ( 28552196)	Asthma (time to childhood onset) in early life tobacco smoke exposure ( 31379025) Asthma (time to childhood onset) x early life tobacco smoke interaction ( 31379025) Bilirubin levels ( 22085899) Chronotype ( 30696823) Cleft lip with or without cleft palate x maternal periconceptional vitamin use interaction (parent of origin effect) ( 31372216) Cognitive performance ( 19734545) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Mortality in sepsis ( 27639821) Obesity-related traits ( 23251661) Photic sneeze reflex ( 27182965) Response to amphetamines ( 22952603) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Tonsillectomy ( 27182965 28928442) Trigger finger ( 32740585) Verbal declarative memory ( 25648963)
Interacting Genes		65 interacting genes: AMHR2 APP ARHGEF6 BAMBI BMP15 BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR2 CDK14 CDK4 CHN1 DCAF12 DCAF6 DCAF7 FANCL GDF5 GDF6 GDF9 KLHL1 LZTR1 NKIRAS1 OTUB1 OXSR1 PAK1 PLEKHB1 POMK PPP2CA PPP3CC RAB25 RAB38 RAB6B RAN RAP2A RASD2 RASL12 RHEBL1 RHOD RHOJ RPS27A RRAS2 SASH3 SH3KBP1 SLC39A8 SMAD6 SMAD7 SNX6 SOCS6 SQSTM1 SRGAP1 STAMBP STK35 STUB1 TGFBR1 TNNT1 TRAF6 TTC17 TTC27 UBA52 UBE2Z UBXN1 USP45 VEPH1	2 interacting genes: BMPR1B TGFBR1
Entrez ID		658	57626
HPRD ID		04457	05623
Ensembl ID		ENSG00000138696	ENSG00000150361
Uniprot IDs		A8KAE3 O00238	B7Z3I8 F5H1J3 Q8TBJ7 Q9NR64
PDB IDs		3MDY
Enriched GO Terms of Interacting Partners?
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