MSRB3 and PLEKHG4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		MSRB3	PLEKHG4
Description		methionine sulfoxide reductase B3	pleckstrin homology and RhoGEF domain containing G4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol	Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Peptide-methionine (R)-S-oxide Reductase Activity L-methionine-(R)-S-oxide Reductase Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Response To Oxidative Stress Protein Repair	Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Protein repair	RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Antisaccade task score ( 31596458) Birth weight ( 31043758) Body shape index ( 34021172) Brain morphology (MOSTest) ( 32665545) Cortical surface area ( 32963231) Cortical volume ( 32963231) Dentate gyrus granule cell layer volume ( 30279459) Dentate gyrus molecular layer volume ( 30279459) Differentiated thyroid cancer ( 28703219) FEV1 ( 30804560) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) Height ( 31562340) Hippocampal fissure volume ( 30279459) Hippocampal subfield CA1 volume ( 30279459) Hippocampal subfield CA1 volume (corrected for total hippocampal volume) ( 30279459) Hippocampal subfield CA3 volume ( 30279459) Hippocampal subfield CA4 volume ( 30279459) Hippocampal volume ( 28098162 22504421) Lung function (FEV1) ( 28166213) Lung function (FVC) ( 30804560) Papillary thyroid cancer ( 28703219) Peak expiratory flow ( 30804560) Post bronchodilator FEV1/FVC ratio ( 26634245) Primary tooth development (number of teeth) ( 23704328 20195514) Primary tooth development (time to first tooth eruption) ( 23704328 20195514) Subcortical brain region volumes ( 25607358) Subiculum volume ( 30279459) Temperament ( 22832960) Temporal lobe volume ( 31396565) Total hippocampal volume ( 30279459) Type 2 diabetes nephropathy ( 21150874)	Blood protein levels ( 29875488 28240269) Body shape index ( 34021172) Heel bone mineral density ( 28869591) High density lipoprotein cholesterol levels ( 33339817) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		32 interacting genes: ASB13 BANP CTBP2 EEF1AKMT3 EFEMP1 EIF6 FAM168B FHL3 GOLGA2 KRT31 KRT34 KRT40 LCN2 LNX2 MAPK8IP2 MED12L METTL15 METTL21A MGLL PICK1 PLEKHG4 POU6F2 PRDM4 REL TCF4 TRIM23 TRIM55 TRIM63 TRIP6 UFSP1 WDR61 ZMYND12	66 interacting genes: A1CF ARHGEF5 ARMC7 BEX2 CCDC120 CCDC187 CDC42 CDKN2C CHIC2 COIL DCUN1D5 DPPA3 DTX2 DUSP13 FAM161A FGD2 GATA3 GCM2 GSTZ1 HCK HOXB9 HOXC8 KRT3 KRT75 MALSU1 MATR3 MDFI METAP1 MSRB3 MTA1 MYEF2 MYOZ1 NATD1 OTX1 PFKFB1 PKP2 PLA2G15 PPP1R32 PRPF18 PRPF31 PSMB1 RHOA RIN1 SAXO1 SETD5 SH2D4A SHISA6 SIX1 SMCP SMG9 TBC1D22B TBX18 TEKT3 TENT5D TFAP2D TFG TRIM55 TRIM63 TSSK3 TTC23 USP2 VPS37C ZCCHC14 ZNF148 ZNF319 ZNF648
Entrez ID		253827	25894
HPRD ID		14785	10890
Ensembl ID		ENSG00000174099	ENSG00000196155
Uniprot IDs		Q8IXL7	A0A024R6X4 Q58EX7
PDB IDs		6QA0
Enriched GO Terms of Interacting Partners?
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