MTREX and MPHOSPH6

Number of citations of the paper that reports this interaction (PubMedID 30033366)
59

Data Source:
BioGRID (genetic interference, affinity chromatography technology)
HPRD (two hybrid)

		MTREX	MPHOSPH6
Description		Mtr4 exosome RNA helicase	M-phase phosphoprotein 6
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Nuclear Speck TRAMP Complex Catalytic Step 2 Spliceosome	Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytosol
	Molecular Function	RNA Binding RNA Helicase Activity Protein Binding ATP Binding ATP Hydrolysis Activity	RNA Binding Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome Maturation Of 5.8S RRNA RRNA Processing RNA Catabolic Process Cellular Response To DNA Damage Stimulus SnRNA Catabolic Process	Maturation Of 5.8S RRNA
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol mRNA Splicing - Major Pathway	Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS			Leukocyte telomere length ( 32109421 31171785) Lung adenocarcinoma ( 28604730) Nevus count or cutaneous melanoma ( 32341527) Obesity-related traits ( 23251661) Parkinson's disease motor subtype (tremor dominant vs postural instability/gait difficulty) ( 33987465) Seasonality and depression ( 30217971)
Interacting Genes		15 interacting genes: DIS3 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FAM107A MPHOSPH6 PALS2 PBX2 SP1 UPF2 XRN1	30 interacting genes: AATF APLP1 ARHGAP18 DNM2 DYNLRB1 EIF3G ERG28 EXOSC10 EXOSC3 EXOSC5 EXOSC7 EXOSC8 FTL GDF9 HSBP1 HSPB1 KNSTRN LRIF1 MTREX NUPR1 PARN RBM48 RPS20 SMARCA4 SNX9 THOP1 TLE1 TP53 UNC119 ZHX1
Entrez ID		23517	10200
HPRD ID		13777	16111
Ensembl ID		ENSG00000039123	ENSG00000135698
Uniprot IDs		P42285 Q3MHC9	H3BNT4 Q99547
PDB IDs		6C90 6D6Q 6D6R 6IEG 6IEH 6RO1	6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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