MTREX and EXOSC5

Number of citations of the paper that reports this interaction (PubMedID 11719186)
354

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		MTREX	EXOSC5
Description		Mtr4 exosome RNA helicase	exosome component 5
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Nuclear Speck TRAMP Complex Catalytic Step 2 Spliceosome	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin
	Molecular Function	RNA Binding RNA Helicase Activity Protein Binding ATP Binding ATP Hydrolysis Activity	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome Maturation Of 5.8S RRNA RRNA Processing RNA Catabolic Process Cellular Response To DNA Damage Stimulus SnRNA Catabolic Process	RRNA Processing RRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Exonucleolytic Catabolism Of Deadenylated MRNA DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Polyadenylation-dependent SnoRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol mRNA Splicing - Major Pathway	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS
Interacting Genes		15 interacting genes: DIS3 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FAM107A MPHOSPH6 PALS2 PBX2 SP1 UPF2 XRN1	83 interacting genes: ACOT11 ADAMTSL4 BIRC2 BORCS6 CALCOCO2 CCDC88B CDK5RAP1 DAAM2 DDIT4L DHRS2 DIS3 DMRTB1 DOCK8 EFHC2 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FCHO1 FH FHL3 GOLGA2 HAMP HOXC4 IKZF3 KCTD13 KIAA1217 KMT2A KRT13 KRT27 KRT31 KRT34 KRT35 LCA5L LIPG LRMDA LSM3 LSM5 LZTS2 MEOX2 MPHOSPH6 MTMR3 MTREX MYLIP NKAPD1 NMI NUP210 PA2G4 PAF1 PALS2 PEG10 PICK1 PIH1D2 PKM POLR2L PRDM6 PRODH2 PTEN REL SFPQ SH3GLB1 SH3GLB2 SHISA6 SNW1 SPTA1 TEX11 TFIP11 TLE5 TNFAIP1 TRIB3 TRIM54 TRIM62 ZFP90 ZMAT1 ZNF420 ZNF558 ZNF620 ZNF655 ZNF792
Entrez ID		23517	56915
HPRD ID		13777	16222
Ensembl ID		ENSG00000039123	ENSG00000077348
Uniprot IDs		P42285 Q3MHC9	Q9NQT4
PDB IDs		6C90 6D6Q 6D6R 6IEG 6IEH 6RO1	2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?