FLT1 and PGF

Number of citations of the paper that reports this interaction (PubMedID 14684734)
32

Data Source:
HPRD (in vitro)

		FLT1	PGF
Description		fms related receptor tyrosine kinase 1	placental growth factor
Image
GO Annotations	Cellular Component	Extracellular Space Endosome Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Actin Cytoskeleton Receptor Complex	Extracellular Region Extracellular Space Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding ATP Binding Growth Factor Binding Placental Growth Factor-activated Receptor Activity	Vascular Endothelial Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Chemoattractant Activity Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Angiogenesis Hematopoietic Progenitor Cell Differentiation Monocyte Chemotaxis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Positive Regulation Of Cell Population Proliferation Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Migration Positive Regulation Of Kinase Activity Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Receptor-1 Signaling Pathway Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Angiogenesis Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Blood Vessel Morphogenesis Embryonic Morphogenesis Negative Regulation Of Vascular Endothelial Cell Proliferation Hyaloid Vascular Plexus Regression	Response To Hypoxia Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Signal Transduction Cell-cell Signaling Female Pregnancy Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Cell Differentiation Animal Organ Regeneration Cellular Response To Hormone Stimulus Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Chemotaxis Induction Of Positive Chemotaxis Positive Regulation Of Cell Division Positive Regulation Of Mast Cell Chemotaxis
Pathways		Neurophilin interactions with VEGF and VEGFR VEGF binds to VEGFR leading to receptor dimerization	VEGF ligand-receptor interactions VEGF binds to VEGFR leading to receptor dimerization
Drugs		Sorafenib Sunitinib Vatalanib TG-100801 OSI-930 Denibulin ABT-869 IMC-1C11 Pazopanib Axitinib N-(4-chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide Regorafenib Lenvatinib Nintedanib Polaprezinc Foreskin fibroblast (neonatal) Fostamatinib Selpercatinib	Aflibercept
Diseases
GWAS		Acute respiratory distress syndrome in sepsis ( 31982041) Birth weight ( 31043758) Body mass index ( 26426971) Cognitive performance ( 19734545) Coronary artery disease ( 32469254 29212778 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 23364394) Myocardial infarction ( 33532862) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Triglyceride levels ( 32203549)	Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Mood instability ( 29187730) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		33 interacting genes: ALOX5AP ARL2BP ATR CDK8 CRK CTNNB1 FLT3 FYN GRB2 HMGB1 KDR LATS2 MIPEP NCK1 NEDD4 NRP1 NRP2 PGF PIK3R1 PLCG1 PLCG2 PTK2 PTK2B PTPN11 RASSF9 SHC1 SHC2 SRPK1 STAT1 STAT3 VEGFA VEGFB YES1	4 interacting genes: FLT1 NRP1 NRP2 VEGFA
Entrez ID		2321	5228
HPRD ID		01297	03076
Ensembl ID		ENSG00000102755	ENSG00000119630
Uniprot IDs		L7RSL3 P17948	G3XA84 P49763 Q53XY6 Q86TW6
PDB IDs		1FLT 1QSV 1QSZ 1QTY 1RV6 2XAC 3HNG 4CKV 4CL7 5ABD 5EX3 5T89	1FZV 1RV6
Enriched GO Terms of Interacting Partners?
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