SMG1 and SMG5

Number of citations of the paper that reports this interaction (PubMedID 14636577)
142

Data Source:
HPRD (in vivo)

		SMG1	SMG5
Description		SMG1 nonsense mediated mRNA decay associated PI3K related kinase	SMG5 nonsense mediated mRNA decay factor
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol TORC1 Complex TORC2 Complex	Nucleus Telomerase Holoenzyme Complex Cytoplasm Cytosol
	Molecular Function	RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Binding ATP Binding Telomeric DNA Binding Metal Ion Binding Protein Serine Kinase Activity	Protein Binding Ubiquitin Protein Ligase Binding Telomeric DNA Binding Histone Deacetylase Binding Protein Phosphatase 2A Binding Telomerase RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay DNA Repair MRNA Export From Nucleus Negative Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Regulation Of Telomere Maintenance TORC1 Signaling Protein Autophosphorylation Phosphatidylinositol Phosphate Biosynthetic Process Regulation Of Response To DNA Damage Stimulus	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Export From Nucleus Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Dephosphorylation
Pathways		Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Health literacy ( 31250787) Heel bone mineral density ( 30598549) Refractive error ( 32231278)	Glycated hemoglobin levels ( 29170429) Hemoglobin A1c levels ( 29403010) Mean corpuscular hemoglobin concentration ( 29403010 20139978)
Interacting Genes		10 interacting genes: CDH5 ELOB PRKCI SMAD9 SMG5 SMG8 SNAPIN UPF1 UPF2 UPF3A	9 interacting genes: APP CKB PLEKHO1 SMG1 SMG6 SMG7 STUB1 TERT UPF1
Entrez ID		23049	23381
HPRD ID		06123	16869
Ensembl ID		ENSG00000157106	ENSG00000198952
Uniprot IDs		Q96Q15	Q9UPR3
PDB IDs		6L53 6L54 6SYT 6Z3R	2HWY
Enriched GO Terms of Interacting Partners?
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