TMCC1 and PLXND1

		TMCC1	PLXND1
Description		transmembrane and coiled-coil domain family 1	plexin D1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Cytosol Endomembrane System Integral Component Of Membrane Endoplasmic Reticulum-endosome Membrane Contact Site	Semaphorin Receptor Complex Plasma Membrane Integral Component Of Plasma Membrane Lamellipodium Lamellipodium Membrane
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding Semaphorin Receptor Activity Protein Domain Specific Binding
	Biological Process	Endoplasmic Reticulum Organization Endosomal Transport Membrane Fission Endosome Membrane Tubulation Endosome Fission	Angiogenesis Branching Involved In Blood Vessel Morphogenesis Kidney Development Outflow Tract Morphogenesis Cardiac Septum Development Negative Regulation Of Cell Adhesion Synapse Assembly Regulation Of Cell Shape Regulation Of Cell Migration Positive Regulation Of Protein Binding Aorta Development Regulation Of GTPase Activity Endothelial Cell Migration Regulation Of Angiogenesis Positive Regulation Of Axonogenesis Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Coronary Vasculature Development Semaphorin-plexin Signaling Pathway Semaphorin-plexin Signaling Pathway Involved In Axon Guidance
Pathways			Other semaphorin interactions NOTCH3 Intracellular Domain Regulates Transcription RND2 GTPase cycle
Drugs
Diseases
GWAS		Body shape index ( 34021172) Breast size ( 22747683) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Type 2 diabetes ( 30297969) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Body shape index ( 34021172) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 34021172 25673412) Hip index ( 34021172) Low density lipoprotein cholesterol levels ( 32154731) Mean platelet volume ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		5 interacting genes: ACAD9 APP PLXND1 RAB7A ZDHHC17	8 interacting genes: H1-10 HOXB5 ISY1 MACF1 PODXL2 SEC61A1 SEMA4A TMCC1
Entrez ID		23023	23129
HPRD ID		15518	05046
Ensembl ID		ENSG00000172765	ENSG00000004399
Uniprot IDs		E9PC87 O94876	Q9Y4D7
PDB IDs			3H6N
Enriched GO Terms of Interacting Partners?
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