TMCC1 and RAB7A

		TMCC1	RAB7A
Description		transmembrane and coiled-coil domain family 1	RAB7A, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Cytosol Endomembrane System Integral Component Of Membrane Endoplasmic Reticulum-endosome Membrane Contact Site	Autophagosome Membrane Lysosome Lysosomal Membrane Late Endosome Lipid Droplet Cytosol Plasma Membrane Endosome Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Late Endosome Membrane Extrinsic Component Of Lysosome Membrane Melanosome Membrane Phagocytic Vesicle Extracellular Exosome
	Molecular Function	Protein Binding Identical Protein Binding	GTPase Activity G Protein Activity Protein Binding GTP Binding GDP Binding Retromer Complex Binding
	Biological Process	Endoplasmic Reticulum Organization Endosomal Transport Membrane Fission Endosome Membrane Tubulation Endosome Fission	Autophagosome Assembly Protein Targeting To Lysosome Endocytosis Epidermal Growth Factor Catabolic Process Endosome To Lysosome Transport Protein Transport Lipid Catabolic Process Viral Release From Host Cell Protein To Membrane Docking Retrograde Transport, Endosome To Golgi Early Endosome To Late Endosome Transport Positive Regulation Of Protein Catabolic Process Positive Regulation Of Viral Process Lipophagy Phagosome Maturation Phagosome Acidification Phagosome-lysosome Fusion Endosome To Plasma Membrane Protein Transport Multi-organism Intercellular Transport Negative Regulation Of Exosomal Secretion Positive Regulation Of Exosomal Secretion Negative Regulation Of Intralumenal Vesicle Formation
Pathways			MHC class II antigen presentation Neutrophil degranulation TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle Prevention of phagosomal-lysosomal fusion Suppression of autophagy
Drugs			Guanosine-5'-Diphosphate
Diseases
GWAS		Body shape index ( 34021172) Breast size ( 22747683) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Type 2 diabetes ( 30297969) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Body fat mass ( 28552196) Facial morphology traits (63 three-dimensional facial segments) ( 29459680)
Interacting Genes		5 interacting genes: ACAD9 APP PLXND1 RAB7A ZDHHC17	35 interacting genes: CHM COPG1 ENOPH1 FABP6 GP9 H1-10 KRTAP10-3 KRTAP10-9 PPP2R1A PPP2R1B PRKN RAB13 RAB17 RAB22A RAB4A RAB4B RAB6A RABAC1 RABGGTB RILP RNF115 RPN1 SLC2A4 SNX3 TMCC1 TP53 UCHL5 VPS11 VPS16 VPS18 VPS26A VPS29 VPS39 VPS41 ZHX2
Entrez ID		23023	7879
HPRD ID		15518	03805
Ensembl ID		ENSG00000172765	ENSG00000075785
Uniprot IDs		E9PC87 O94876	A0A158RFU6 P51149
PDB IDs			1T91 1YHN 3LAW 6IYB 6WCW
Enriched GO Terms of Interacting Partners?
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