PLXND1 and SEC61A1

		PLXND1	SEC61A1
Description		plexin D1	SEC61 translocon subunit alpha 1
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GO Annotations	Cellular Component	Semaphorin Receptor Complex Plasma Membrane Integral Component Of Plasma Membrane Lamellipodium Lamellipodium Membrane	Sec61 Translocon Complex Endoplasmic Reticulum Membrane Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding Semaphorin Receptor Activity Protein Domain Specific Binding	Signal Sequence Binding Calcium Channel Activity Protein Binding Protein Transmembrane Transporter Activity Ribosome Binding
	Biological Process	Angiogenesis Branching Involved In Blood Vessel Morphogenesis Kidney Development Outflow Tract Morphogenesis Cardiac Septum Development Negative Regulation Of Cell Adhesion Synapse Assembly Regulation Of Cell Shape Regulation Of Cell Migration Positive Regulation Of Protein Binding Aorta Development Regulation Of GTPase Activity Endothelial Cell Migration Regulation Of Angiogenesis Positive Regulation Of Axonogenesis Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Coronary Vasculature Development Semaphorin-plexin Signaling Pathway Semaphorin-plexin Signaling Pathway Involved In Axon Guidance	Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Posttranslational Protein Targeting To Endoplasmic Reticulum Membrane Endoplasmic Reticulum Organization Posttranslational Protein Targeting To Membrane, Translocation Response To Interferon-gamma Pronephric Nephron Development Protein Targeting To ER Calcium Ion Transmembrane Transport
Pathways		Other semaphorin interactions NOTCH3 Intracellular Domain Regulates Transcription RND2 GTPase cycle	ER-Phagosome pathway SRP-dependent cotranslational protein targeting to membrane
Drugs
Diseases
GWAS		Body shape index ( 34021172) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 34021172 25673412) Hip index ( 34021172) Low density lipoprotein cholesterol levels ( 32154731) Mean platelet volume ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)	Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Gestational age at birth (maternal effect) ( 28877031)
Interacting Genes		8 interacting genes: H1-10 HOXB5 ISY1 MACF1 PODXL2 SEC61A1 SEMA4A TMCC1	12 interacting genes: ACAD9 BAG6 CALM1 GET3 HSPA5 MLH1 PLXND1 PTEN SEC61G SERP1 SLC13A1 TNF
Entrez ID		23129	29927
HPRD ID		05046	15316
Ensembl ID		ENSG00000004399	ENSG00000058262
Uniprot IDs		Q9Y4D7	B3KME8 B3KNF6 P61619
PDB IDs		3H6N	6W6L
Enriched GO Terms of Interacting Partners?
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