DIS3 and MTREX

Number of citations of the paper that reports this interaction (PubMedID 11719186)
354

Data Source:
HPRD (in vivo)

		DIS3	MTREX
Description		DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease	Mtr4 exosome RNA helicase
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytosol Membrane	Nucleus Nucleoplasm Nucleolus Nuclear Speck TRAMP Complex Catalytic Step 2 Spliceosome
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Endonuclease Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding	RNA Binding RNA Helicase Activity Protein Binding ATP Binding ATP Hydrolysis Activity
	Biological Process	RRNA Processing RRNA Catabolic Process Exonucleolytic Catabolism Of Deadenylated MRNA Regulation Of Catalytic Activity CUT Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	MRNA Splicing, Via Spliceosome Maturation Of 5.8S RRNA RRNA Processing RNA Catabolic Process Cellular Response To DNA Damage Stimulus SnRNA Catabolic Process
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol	Major pathway of rRNA processing in the nucleolus and cytosol mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Restless legs syndrome ( 29029846)
Interacting Genes		12 interacting genes: EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 MTREX NTMT1 PALS2 ZBTB17	15 interacting genes: DIS3 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FAM107A MPHOSPH6 PALS2 PBX2 SP1 UPF2 XRN1
Entrez ID		22894	23517
HPRD ID		06338	13777
Ensembl ID		ENSG00000083520	ENSG00000039123
Uniprot IDs		G3V1J5 Q9Y2L1	P42285 Q3MHC9
PDB IDs		6D6Q 6D6R 6H25	6C90 6D6Q 6D6R 6IEG 6IEH 6RO1
Enriched GO Terms of Interacting Partners?
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