LMTK2 and TPTE2

Number of citations of the paper that reports this interaction (PubMedID 28065597)
37

Data Source:
BioGRID (two hybrid)

		LMTK2	TPTE2
Description		lemur tyrosine kinase 2	transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Early Endosome Golgi Apparatus Cytosol Integral Component Of Plasma Membrane Integral Component Of Membrane Growth Cone Neuronal Cell Body Receptor Complex Perinuclear Region Of Cytoplasm Recycling Endosome	Golgi Membrane Nucleus Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Integral Component Of Membrane Cell Projection
	Molecular Function	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Phosphatase Inhibitor Activity Protein Binding ATP Binding Myosin VI Binding Protein Serine Kinase Activity	Protein Tyrosine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity
	Biological Process	Receptor Recycling Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axonogenesis Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Endocytic Recycling Transferrin Transport Positive Regulation Of Kinase Activity Negative Regulation Of Catalytic Activity Early Endosome To Late Endosome Transport Protein Autophosphorylation	Protein Dephosphorylation Phosphatidylinositol Biosynthetic Process Negative Regulation Of Cell Population Proliferation Phosphatidylinositol 3-kinase Signaling Dephosphorylation Peptidyl-tyrosine Dephosphorylation Phosphatidylinositol Dephosphorylation Cell Motility Regulation Of Protein Kinase B Signaling
Pathways			Synthesis of PIPs at the Golgi membrane
Drugs
Diseases
GWAS		Gamma glutamyl transferase levels ( 29403010 33339817) Hemoglobin levels ( 32327693) Prostate cancer ( 18264097) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408)	Liver fibrosis (total hepatic collagen content) ( 32953199)
Interacting Genes		24 interacting genes: CDC14A CDC25C CDK5 CDK5R1 DUSP14 DUSP19 DUSP29 DUSP6 ILKAP MTMR6 PPM1A PPM1F PPM1K PPP1CA PPP1CB PPP1CC PPP1R2 PPP3CB PTPDC1 PTPN12 PTPN6 PTPRR STYX TPTE2	5 interacting genes: AATK BRCA1 EPHA2 LMTK2 PTK7
Entrez ID		22853	93492
HPRD ID		13994	06003
Ensembl ID		ENSG00000164715	ENSG00000132958
Uniprot IDs		Q8IWU2	Q6XPS3
PDB IDs
Enriched GO Terms of Interacting Partners?
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