FKBP1B and RYR2

Number of citations of the paper that reports this interaction (PubMedID 10830164)
611

Data Source:
BioGRID (affinity chromatography technology, fluorescent resonance energy transfer, pull down)
HPRD (two hybrid, in vitro, in vivo)

		FKBP1B	RYR2
Description		FKBP prolyl isomerase 1B	ryanodine receptor 2
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Z Disc Sarcoplasmic Reticulum Membrane Calcium Channel Complex	Smooth Endoplasmic Reticulum Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Z Disc Cytoplasmic Vesicle Membrane Protein-containing Complex Sarcoplasmic Reticulum Membrane Calcium Channel Complex Sarcolemma
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Signaling Receptor Binding Ryanodine-sensitive Calcium-release Channel Activity Protein Binding FK506 Binding Calcium Channel Inhibitor Activity Cyclic Nucleotide Binding Transmembrane Transporter Binding	Ryanodine-sensitive Calcium-release Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calmodulin Binding Calcium-release Channel Activity Enzyme Binding Protein Kinase A Catalytic Subunit Binding Protein Kinase A Regulatory Subunit Binding Identical Protein Binding Suramin Binding Transmembrane Transporter Binding Calcium-induced Calcium Release Activity
	Biological Process	Protein Peptidyl-prolyl Isomerization 'de Novo' Protein Folding Smooth Muscle Contraction Response To Glucose Negative Regulation Of Heart Rate Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Neuronal Action Potential Propagation Protein Maturation By Protein Folding Insulin Secretion Negative Regulation Of Phosphoprotein Phosphatase Activity Response To Vitamin E Calcium-mediated Signaling Using Intracellular Calcium Source Protein Refolding T Cell Proliferation Response To Hydrogen Peroxide Positive Regulation Of Axon Regeneration Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Cytosolic Calcium Ion Concentration Response To Redox State Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Chaperone-mediated Protein Folding Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cell Communication By Electrical Coupling Involved In Cardiac Conduction	Response To Hypoxia Regulation Of Heart Rate Embryonic Heart Tube Morphogenesis Left Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Hypertrophy Detection Of Calcium Ion Calcium Ion Transport Cellular Calcium Ion Homeostasis Positive Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Muscle Activity Calcium-mediated Signaling Response To Caffeine Calcium-mediated Signaling Using Intracellular Calcium Source Response To Muscle Stretch Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Cytosolic Calcium Ion Concentration Response To Redox State Regulation Of Cardiac Muscle Contraction Cardiac Muscle Contraction Calcium Ion Transport Into Cytosol Sarcoplasmic Reticulum Calcium Ion Transport Cellular Response To Caffeine Cellular Response To Epinephrine Stimulus Establishment Of Protein Localization To Endoplasmic Reticulum Ventricular Cardiac Muscle Cell Action Potential Purkinje Myocyte To Ventricular Cardiac Muscle Cell Signaling Cell Communication By Electrical Coupling Involved In Cardiac Conduction Type B Pancreatic Cell Apoptotic Process Positive Regulation Of The Force Of Heart Contraction Regulation Of AV Node Cell Action Potential Regulation Of SA Node Cell Action Potential Regulation Of Atrial Cardiac Muscle Cell Action Potential Regulation Of Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity
Pathways		Stimuli-sensing channels Ion homeostasis	Stimuli-sensing channels Ion homeostasis
Drugs			Flecainide Tetracaine
Diseases
GWAS		Chronotype ( 27494321) Quantitative traits ( 19197348)	Acute lymphoblastic leukemia (childhood) ( 19684603) Bipolar disorder and eating disorder ( 26433762) Cerivastatin-induced rhabdomyolysis ( 21386754) cognitive impairment (MMSE score) in Parkinsonâ€™s disease ( 33613413) Exercise treadmill test traits ( 17903301) General risk tolerance (MTAG) ( 30643258) Hippocampal volume ( 31530798) Hypertension ( 17554300) Lipid traits ( 30576415 24386095) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Postoperative stroke after cardiac surgery ( 30678657) PR interval ( 32439900) Response to taxane treatment (docetaxel) ( 23006423) Smoking initiation (ever regular vs never regular) ( 30679032)
Interacting Genes		12 interacting genes: ADAMTSL4 BMPR1A CAMK2D GMCL1 KRT31 KRT40 KRTAP1-1 REL RYR2 RYR3 TGFBR1 TRIM69	16 interacting genes: AKAP6 ALB CACNA1C FKBP1B HOMER1 HSPB2 ITPR1 LINC00839 MDM2 PRKACA PRKAR2A PSEN1 RYR1 RYR3 SMAD5 SRI
Entrez ID		2281	6262
HPRD ID		02795	01619
Ensembl ID		ENSG00000119782	ENSG00000198626
Uniprot IDs		F8W6G9 P68106	Q92736
PDB IDs		1C9H 4C02 4IQ2 4IQC 5HKG 5L1D 5T15 5T9M 5T9N 5T9R 5T9S 5T9V 5TA3 5TAL 5TAM 5TAN 5TAP 5TAQ 5TAS 5TAT 5TAU 5TAV 5TAW 5TAX 5TAY 5TAZ 5TB0 5TB1 5TB2 5TB3 5TB4 6JGZ 6JH6 6JHN 6JI0 6JI8 6JII 6JIU 6JIY 6JRR 6JRS 6M2W 6PV6 6W1N 6WOT 6WOU 6WOV 6X32 6X33 6X34 6X35 6X36 7CF9 7JMF 7JMG 7JMH 7JMI 7JMJ	4JKQ 6Y4O 6Y4P
Enriched GO Terms of Interacting Partners?
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