FKBP1B and TRIM69

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid, two hybrid)

		FKBP1B	TRIM69
Description		FKBP prolyl isomerase 1B	tripartite motif containing 69
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GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Z Disc Sarcoplasmic Reticulum Membrane Calcium Channel Complex	Nucleus Cytoplasm Cytosol Nuclear Speck
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Signaling Receptor Binding Ryanodine-sensitive Calcium-release Channel Activity Protein Binding FK506 Binding Calcium Channel Inhibitor Activity Cyclic Nucleotide Binding Transmembrane Transporter Binding	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Peptidyl-prolyl Isomerization 'de Novo' Protein Folding Smooth Muscle Contraction Response To Glucose Negative Regulation Of Heart Rate Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Neuronal Action Potential Propagation Protein Maturation By Protein Folding Insulin Secretion Negative Regulation Of Phosphoprotein Phosphatase Activity Response To Vitamin E Calcium-mediated Signaling Using Intracellular Calcium Source Protein Refolding T Cell Proliferation Response To Hydrogen Peroxide Positive Regulation Of Axon Regeneration Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Cytosolic Calcium Ion Concentration Response To Redox State Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Chaperone-mediated Protein Folding Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cell Communication By Electrical Coupling Involved In Cardiac Conduction	Apoptotic Process Protein Ubiquitination
Pathways		Stimuli-sensing channels Ion homeostasis	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Chronotype ( 27494321) Quantitative traits ( 19197348)	Estimated glomerular filtration rate in non-diabetics ( 31451708)
Interacting Genes		12 interacting genes: ADAMTSL4 BMPR1A CAMK2D GMCL1 KRT31 KRT40 KRTAP1-1 REL RYR2 RYR3 TGFBR1 TRIM69	53 interacting genes: AIFM2 APP ASNS ATP5MC1 BEX2 BIN3 C4orf45 CDSN DVL1 ETFDH FAM110A FAM161A FAM90A1 FKBP1B GEM HAUS1 HGS IYD KLHL38 KRT17 LARP1B LYSMD1 MAGEA4 MAJIN MED20 MID2 NEK8 NTAQ1 PML POLR3K PPP1R18 RECK RINT1 RSPH14 SF1 SF3A3 SKIL STMN3 SYCE2 SYNE4 TNNT2 TRIM44 TRIM54 TRIM55 TRIM63 UBE2D1 UBE2D3 UBE2E1 UBE2H UBE2N WASHC1 WWOX ZNF483
Entrez ID		2281	140691
HPRD ID		02795	11518
Ensembl ID		ENSG00000119782	ENSG00000185880
Uniprot IDs		F8W6G9 P68106	H0YL66 Q86WT6
PDB IDs		1C9H 4C02 4IQ2 4IQC 5HKG 5L1D 5T15 5T9M 5T9N 5T9R 5T9S 5T9V 5TA3 5TAL 5TAM 5TAN 5TAP 5TAQ 5TAS 5TAT 5TAU 5TAV 5TAW 5TAX 5TAY 5TAZ 5TB0 5TB1 5TB2 5TB3 5TB4 6JGZ 6JH6 6JHN 6JI0 6JI8 6JII 6JIU 6JIY 6JRR 6JRS 6M2W 6PV6 6W1N 6WOT 6WOU 6WOV 6X32 6X33 6X34 6X35 6X36 7CF9 7JMF 7JMG 7JMH 7JMI 7JMJ	4NQJ 6YXE
Enriched GO Terms of Interacting Partners?
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