FGF8 and FGFR1

Number of citations of the paper that reports this interaction (PubMedID 10574949)
17

Data Source:
HPRD (in vitro, in vivo)

		FGF8	FGFR1
Description		fibroblast growth factor 8	fibroblast growth factor receptor 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm External Side Of Plasma Membrane	Extracellular Region Nucleus Cytosol Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Cytoplasmic Vesicle Receptor Complex
	Molecular Function	Fibroblast Growth Factor Receptor Binding Type 1 Fibroblast Growth Factor Receptor Binding Type 2 Fibroblast Growth Factor Receptor Binding Growth Factor Activity Chemoattractant Activity	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Fibroblast Growth Factor-activated Receptor Activity Protein Binding ATP Binding Heparin Binding Fibroblast Growth Factor Binding Identical Protein Binding Protein Homodimerization Activity Receptor-receptor Interaction
	Biological Process	MAPK Cascade Branching Involved In Blood Vessel Morphogenesis Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Organ Induction Mesonephros Development Neural Plate Morphogenesis Positive Regulation Of Protein Phosphorylation Heart Looping Blood Vessel Remodeling Heart Morphogenesis Outflow Tract Septum Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Response To Oxidative Stress Gastrulation Motor Neuron Axon Guidance Mesodermal Cell Migration Positive Regulation Of Cell Population Proliferation Gonad Development Fibroblast Growth Factor Receptor Signaling Pathway Response To Xenobiotic Stimulus Anatomical Structure Morphogenesis Animal Organ Morphogenesis Dorsal/ventral Pattern Formation Positive Regulation Of Gene Expression Response To Organic Cyclic Compound Pallium Development Subpallium Development Forebrain Dorsal/ventral Pattern Formation Cell Proliferation In Forebrain Forebrain Neuron Development Signal Transduction Involved In Regulation Of Gene Expression Cell Differentiation Neuron Differentiation Regulation Of Cell Migration Male Genitalia Development Thyroid Gland Development Otic Vesicle Formation Midbrain-hindbrain Boundary Development Dorsal/ventral Axon Guidance Embryonic Heart Tube Development Limb Morphogenesis Embryonic Hindlimb Morphogenesis Aorta Morphogenesis Odontogenesis Regulation Of Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Neuron Apoptotic Process Cell Fate Commitment Positive Regulation Of Cell Differentiation Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Organ Growth Embryonic Neurocranium Morphogenesis Forebrain Morphogenesis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Cell Division Negative Regulation Of Cardiac Muscle Tissue Development Pharyngeal System Development Corticotropin Hormone Secreting Cell Differentiation Thyroid-stimulating Hormone-secreting Cell Differentiation Bone Development Lung Morphogenesis Branching Involved In Salivary Gland Morphogenesis Neuroepithelial Cell Differentiation Positive Regulation Of ERK1 And ERK2 Cascade Dopaminergic Neuron Differentiation Cell Migration Involved In Mesendoderm Migration Larynx Morphogenesis	MAPK Cascade Skeletal System Development Neuron Migration Epithelial To Mesenchymal Transition Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Peptidyl-tyrosine Phosphorylation Positive Regulation Of Kinase Activity Chordate Embryonic Development Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Neuron Differentiation Protein Autophosphorylation Phosphatidylinositol-mediated Signaling Skeletal System Morphogenesis Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Signaling by activated point mutants of FGFR1 Signaling by FGFR1 in disease Signaling by plasma membrane FGFR1 fusions
Drugs			Palifermin Sorafenib Heparin 3-[4-(1-formylpiperazin-4-yl)-benzylidenyl]-2-indolinone XL999 3-(3-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridine (E)-[4-(3,5-Difluorophenyl)-3H-pyrrolo[2,3-b]pyridin-3-ylidene](3-methoxyphenyl)methanol 3-[(3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE Regorafenib Ponatinib Lenvatinib Nintedanib Fostamatinib Erdafitinib Pemigatinib Selpercatinib Pralsetinib
Diseases
GWAS		General cognitive ability ( 29844566) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Systolic blood pressure ( 30578418)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Birth weight ( 31043758) Body size at age 10 ( 32376654) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Nonsyndromic cleft lip with cleft palate ( 28232668) PR interval ( 30046033 32439900) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Schizophrenia ( 29483656) Triglyceride levels ( 32203549) Type 2 diabetes ( 32499647)
Interacting Genes		5 interacting genes: FGFR1 FGFR2 FGFR3 FGFR4 PTX3	74 interacting genes: BNIP2 CDH1 CREBBP CRK CTPS2 EIF4EBP1 EPHA4 ERBB2 ERBB3 FBXO7 FDPS FGF1 FGF10 FGF17 FGF18 FGF2 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FLRT3 FRS2 FRS3 GRB14 GRB2 HTR1A HULC IL17RD ITGB3 ITK KLB KPNB1 L1CAM LDHA MFHAS1 MMP2 NCAM1 NCK1 NCK2 NECTIN1 NEDD4 NRG1 NRP1 OR51B4 PDGFRB PDK1 PDP1 PIK3R1 PIK3R2 PKM PLCG1 PPP2CB PTK6 PTPN1 RARA RASA1 RPS6KA1 RPS6KA3 RTN1 RTN3 SH3BP2 SHB SHC1 SLA SOS1 TNK2 TNS2 TPMT VAV1 YES1 ZFYVE1
Entrez ID		2253	2260
HPRD ID		02727	00634
Ensembl ID		ENSG00000107831	ENSG00000077782
Uniprot IDs		A0A087X1S5 A1A515 P55075	A0A0S2Z3Q6 A0A3B3ISD1 P11362
PDB IDs		2FDB	1AGW 1CVS 1EVT 1FGI 1FGK 1FQ9 1XR0 2CR3 2FGI 3C4F 3DPK 3GQI 3GQL 3JS2 3KRJ 3KRL 3KXX 3KY2 3OJV 3RHX 3TT0 4F63 4F64 4F65 4NK9 4NKA 4NKS 4RWI 4RWJ 4RWK 4RWL 4UWB 4UWC 4UWY 4V01 4V04 4V05 4WUN 4ZSA 5A46 5A4C 5AM6 5AM7 5B7V 5EW8 5FLF 5O49 5O4A 5UQ0 5UR1 5VND 5W21 5W59 5Z0S 5ZV2 6C18 6C19 6C1B 6C1C 6C1O 6ITJ 6MZQ 6MZW 6NVL 6P68 6P69
Enriched GO Terms of Interacting Partners?
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