ZBTB9 and DYRK2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		ZBTB9	DYRK2
Description		zinc finger and BTB domain containing 9	dual specificity tyrosine phosphorylation regulated kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Ribonucleoprotein Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Protein Binding Identical Protein Binding Metal Ion Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Manganese Ion Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Protein Phosphorylation Cellular Response To DNA Damage Stimulus Smoothened Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Signal Transduction By P53 Class Mediator
Pathways			Regulation of TP53 Activity through Phosphorylation
Drugs
Diseases
GWAS		Age at smoking initiation in chronic obstructive pulmonary disease ( 21685187) Autism spectrum disorder or schizophrenia ( 28540026) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Crohn's disease or systemic sclerosis ( 32024964) Diastolic blood pressure ( 27841878) Lung cancer ( 28604730)	Amyotrophic lateral sclerosis (C9orf72 mutation interaction) ( 22959728) Daytime sleep phenotypes ( 27126917) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Malaria ( 31844061) Metabolite levels ( 23823483) Mosquito bite size ( 28199695) Systemic lupus erythematosus ( 28714469)
Interacting Genes		47 interacting genes: CAPN7 CBX8 CDYL2 CHURC1 CIB4 CKS1B DTNB DYRK2 EHHADH EIF4E2 GTF2E1 KRTAP1-1 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP12-2 LASP1 MCM6 MDFI MORF4L1 MYBL2 NFKB1 NR3C1 PARP1 PIN1 PIN4 PPARG PPARGC1B SNIP1 SYTL4 TCEA2 TCEANC TSPYL1 TSR2 UBE2I ZBTB24 ZBTB26 ZBTB48 ZFP64 ZFY ZKSCAN5 ZNF23 ZNF407 ZNF408 ZNF417 ZNF71 ZZZ3	22 interacting genes: APP ATM DYRK4 EIF2B5 H2BC21 H3-4 IKZF1 KATNA1 KXD1 LRRK2 LZTS2 MAPT MDM2 NR1I2 RAD54B SIAH2 SP100 TERT UBE2D1 UBR5 WDR62 ZBTB9
Entrez ID		221504	8445
HPRD ID		15695	04606
Ensembl ID		ENSG00000213588	ENSG00000127334
Uniprot IDs		A0A1U9X8U5 Q96C00	Q92630
PDB IDs			3K2L 3KVW 4AZF 5LXC 5LXD 5ZTN 6HDP 6HDR 6K0J
Enriched GO Terms of Interacting Partners?
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