ZBTB9 and MCM6

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		ZBTB9	MCM6
Description		zinc finger and BTB domain containing 9	minichromosome maintenance complex component 6
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Chromosome, Telomeric Region Nucleus Nucleoplasm MCM Complex CMG Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Protein Binding Identical Protein Binding Metal Ion Binding	DNA Helicase Activity Single-stranded DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Single-stranded DNA Helicase Activity Identical Protein Binding Single-stranded 3'-5' DNA Helicase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation Mitotic DNA Replication
Pathways			Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state
Drugs
Diseases
GWAS		Age at smoking initiation in chronic obstructive pulmonary disease ( 21685187) Autism spectrum disorder or schizophrenia ( 28540026) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Crohn's disease or systemic sclerosis ( 32024964) Diastolic blood pressure ( 27841878) Lung cancer ( 28604730)	Aspartate aminotransferase levels ( 33547301) Body fat percentage and LDL-C (pairwise) ( 33619380) Body mass index ( 25673413) Body mass index and LDL-C (pairwise) ( 33619380) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Hip circumference ( 25673412) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)
Interacting Genes		47 interacting genes: CAPN7 CBX8 CDYL2 CHURC1 CIB4 CKS1B DTNB DYRK2 EHHADH EIF4E2 GTF2E1 KRTAP1-1 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP12-2 LASP1 MCM6 MDFI MORF4L1 MYBL2 NFKB1 NR3C1 PARP1 PIN1 PIN4 PPARG PPARGC1B SNIP1 SYTL4 TCEA2 TCEANC TSPYL1 TSR2 UBE2I ZBTB24 ZBTB26 ZBTB48 ZFP64 ZFY ZKSCAN5 ZNF23 ZNF407 ZNF408 ZNF417 ZNF71 ZZZ3	37 interacting genes: C2CD6 CCNA1 CDC42 CDC45 CDC7 CDKN2A CDT1 CHEK1 CRLS1 DBF4 ESCO2 FAM161A GMNN HSPB1 IL36RN ING5 MCM10 MCM2 MCM3 MCM4 MCM7 MCM8 MCMBP MLLT3 MTDH NUDT2 ORC1 ORC2 ORC4 ORC6 PSMA1 RPA1 SCNM1 SMC1A SNRPB2 TRIM28 ZBTB9
Entrez ID		221504	4175
HPRD ID		15695	03485
Ensembl ID		ENSG00000213588	ENSG00000076003
Uniprot IDs		A0A1U9X8U5 Q96C00	Q14566
PDB IDs			2KLQ 2LE8 6XTX 6XTY
Enriched GO Terms of Interacting Partners?
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