CADM4 and CNKSR1

Number of citations of the paper that reports this interaction (PubMedID 16825666)
20

Data Source:
HPRD (two hybrid, in vivo)

		CADM4	CNKSR1
Description		cell adhesion molecule 4	connector enhancer of kinase suppressor of Ras 1
Image		No pdb structure
GO Annotations	Cellular Component	Integral Component Of Membrane Cell Leading Edge Cell-cell Contact Zone	Plasma Membrane Cell-cell Junction Cell Cortex
	Molecular Function	Protein Phosphatase Binding Receptor Tyrosine Kinase Binding Vascular Endothelial Growth Factor Receptor 1 Binding Vascular Endothelial Growth Factor Receptor 2 Binding	Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Regulation Of Protein Phosphorylation Negative Regulation Of Protein Phosphorylation Cell Adhesion Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Rac Protein Signal Transduction Regulation Of Cell Population Proliferation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Wound Healing Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Cell Motility	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Rho Protein Signal Transduction
Pathways			MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs
Diseases
GWAS			Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)
Interacting Genes		3 interacting genes: CNKSR1 CSNK1E DYNC1I1	23 interacting genes: ARHGEF1 BRAP CADM4 CYTH1 CYTH2 CYTH3 CYTH4 MAP2K2 MAP2K7 MAP3K10 PIN1 RAF1 RALGDS RASSF1 RHOA RHPN1 SASH1 SMAD4 STK3 STK4 TCAF1 ZDHHC17 ZGPAT
Entrez ID		199731	10256
HPRD ID		17141	11937
Ensembl ID		ENSG00000105767	ENSG00000142675
Uniprot IDs		Q8NFZ8	B4DL25 G3V160 Q53GM7 Q969H4
PDB IDs			1WWV
Enriched GO Terms of Interacting Partners?
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