CNKSR1

Description		connector enhancer of kinase suppressor of Ras 1
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GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Cell Cortex
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Rho Protein Signal Transduction
Pathways		MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs
Diseases
GWAS		Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)
Interacting Genes		23 interacting genes: ARHGEF1 BRAP CADM4 CYTH1 CYTH2 CYTH3 CYTH4 MAP2K2 MAP2K7 MAP3K10 PIN1 RAF1 RALGDS RASSF1 RHOA RHPN1 SASH1 SMAD4 STK3 STK4 TCAF1 ZDHHC17 ZGPAT
Entrez ID		10256
HPRD ID		11937
Ensembl ID		ENSG00000142675
Uniprot IDs		B4DL25 G3V160 Q53GM7 Q969H4
PDB IDs		1WWV
Enriched GO Terms of Interacting Partners?
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