DRD5 and GNA13

Number of citations of the paper that reports this interaction (PubMedID 12623966)
32

Data Source:
HPRD (in vivo)

		DRD5	GNA13
Description		dopamine receptor D5	G protein subunit alpha 13
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cilium Brush Border Membrane Synapse Ciliary Membrane Non-motile Cilium	Nucleus Cytoplasm Cytosol Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Membrane Brush Border Membrane Melanosome Extracellular Exosome
	Molecular Function	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gs G Protein-coupled Receptor Activity Dopamine Neurotransmitter Receptor Activity Protein Binding Dopamine Binding	G Protein-coupled Receptor Binding GTPase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding D5 Dopamine Receptor Binding Metal Ion Binding
	Biological Process	Synaptic Transmission, Dopaminergic Response To Amphetamine Regulation Of Systemic Arterial Blood Pressure By Vasopressin Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Cellular Calcium Ion Homeostasis Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Chemical Synaptic Transmission Associative Learning Transmission Of Nerve Impulse Negative Regulation Of NAD(P)H Oxidase Activity Wound Healing Response To Cocaine Positive Regulation Of Adenylate Cyclase Activity Negative Regulation Of Blood Pressure Regulation Of Female Receptivity Sensitization Phospholipase C-activating Dopamine Receptor Signaling Pathway Long-term Synaptic Depression Cellular Response To Catecholamine Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Reactive Oxygen Species Metabolic Process	Signal Transduction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Rho Protein Signal Transduction Activation Of Phospholipase D Activity Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways		Dopamine receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	NRAGE signals death through JNK G alpha (12/13) signalling events Thromboxane signalling through TP receptor Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) CDC42 GTPase cycle RAC1 GTPase cycle
Drugs		Ziprasidone Cabergoline Cabergoline Olanzapine Olanzapine Loxapine Loxapine Imipramine Chlorpromazine Chlorpromazine Lamotrigine Cinnarizine Lisuride Ergotamine Apomorphine Paroxetine Trimipramine Fenoldopam Dopamine Dopamine Carphenazine Ergoloid mesylate Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Methotrimeprazine Zuclopenthixol Rotigotine Mianserin Quinagolide Zotepine Dihydro-alpha-ergocryptine Epicriptine Pipradrol Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Gut microbiota (bacterial taxa) ( 27723756) Impulsivity (motor) ( 30718321) Lung cancer ( 28604730) Manganese levels ( 26025379) Metabolite levels ( 23823483)	Brain morphology (MOSTest) ( 32665545) Periventricular white matter hyperintensities ( 32517579) White matter microstructure (global fractional anisotropy) ( 24736177)
Interacting Genes		8 interacting genes: GABRG2 GNA12 GNA13 GNAS GNAZ NBPF19 NCS1 NOTCH2NLA	31 interacting genes: AIP AKAP3 ARHGEF1 ARHGEF11 ARHGEF12 CDH1 CDH2 CTNNB1 CXCR4 DRD5 EDNRB F2R GNA12 GPR17 MCF2 MTNR1A PPP5C PRKACA PRKCB PRKCD PRKCE PTK2B RDX RGS16 RIC8A S1PR2 S1PR3 S1PR4 TBXA2R TGFBR1 TSHR
Entrez ID		1816	10672
HPRD ID		00542	05100
Ensembl ID		ENSG00000169676	ENSG00000120063
Uniprot IDs		P21918	A0A024R8M0 Q14344
PDB IDs
Enriched GO Terms of Interacting Partners?
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