RAC2 and RTKN

Number of citations of the paper that reports this interaction (PubMedID 12516569)
24

Data Source:
HPRD (in vivo)

		RAC2	RTKN
Description		Rac family small GTPase 2	rhotekin
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Cell Cortex Lamellipodium Phagocytic Vesicle Membrane Cytoplasmic Vesicle Cell Projection Extracellular Exosome	Cellular_component Actomyosin Contractile Ring Cytosol
	Molecular Function	GTPase Activity Protein Binding GTP Binding Protein Kinase Regulator Activity Protein Kinase Binding	GTPase Inhibitor Activity Protein Binding GTP Binding Small GTPase Binding
	Biological Process	Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Signal Transduction G Protein-coupled Receptor Signaling Pathway Motor Neuron Axon Guidance Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Lamellipodium Assembly Regulation Of Cell-substrate Adhesion Rac Protein Signal Transduction Cell Projection Assembly Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of T Cell Proliferation Regulation Of Mast Cell Degranulation Engulfment Of Apoptotic Cell Bone Resorption Regulation Of Catalytic Activity Regulation Of Respiratory Burst Regulation Of Mast Cell Chemotaxis Lymphocyte Aggregation Positive Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration Positive Regulation Of Protein Targeting To Mitochondrion	Mitotic Cytokinesis Actomyosin Contractile Ring Assembly Apoptotic Process Signal Transduction Rho Protein Signal Transduction Septin Ring Organization Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity
Pathways		GPVI-mediated activation cascade ROS and RNS production in phagocytes PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PCP/CE pathway RHO GTPases Activate NADPH Oxidases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RAC2 GTPase cycle	RHO GTPases Activate Rhotekin and Rhophilins RHO GTPases Activate Rhotekin and Rhophilins RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle
Drugs		Dextromethorphan
Diseases
GWAS		Celiac disease ( 31591516) Graves' disease ( 23612905) Longevity ( 20834067) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Type 1 diabetes ( 25751624)	Refractive error ( 32231278)
Interacting Genes		24 interacting genes: ACTB ADAM22 AFG3L2 AGAP2 ARFIP2 ARHGDIA ARHGDIB BRD2 CDC42 CHGB CHPF CUL1 DEF6 DOCK2 GDI1 HDAC7 ICMT NCF2 NOS2 NOXA1 PAK2 RTKN SMAD1 SMAD4	11 interacting genes: AKAP13 APP GOPC MAP1LC3A MFHAS1 RAC2 RHOA RHOC SMURF1 TAX1BP3 TGFBR1
Entrez ID		5880	6242
HPRD ID		03628	03795
Ensembl ID		ENSG00000128340	ENSG00000114993
Uniprot IDs		A0A024R1P2 P15153 V9H0H7	Q9BST9
PDB IDs		1DS6 2W2T 2W2V 2W2X
Enriched GO Terms of Interacting Partners?
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