DDB2 and CUL4B

Number of citations of the paper that reports this interaction (PubMedID 18593899)
57

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		DDB2	CUL4B
Description		damage specific DNA binding protein 2	cullin 4B
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cell Junction Cul4B-RING E3 Ubiquitin Ligase Complex Protein-containing Complex Cul4-RING E3 Ubiquitin Ligase Complex	Nucleoplasm Cytosol Cullin-RING Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Extracellular Exosome Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	DNA Binding Damaged DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Protein-containing Complex Binding	Damaged DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Protein Polyubiquitination DNA Repair Nucleotide-excision Repair Pyrimidine Dimer Repair Response To UV Histone H2A Monoubiquitination Protein Autoubiquitination UV-damage Excision Repair	G1/S Transition Of Mitotic Cell Cycle Cellular Response To DNA Damage Stimulus Proteasomal Protein Catabolic Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Neuron Projection Development Histone H2A Monoubiquitination Ribosome Biogenesis UV-damage Excision Repair
Pathways		Ub-specific processing proteases DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER TP53 Regulates Transcription of DNA Repair Genes Neddylation	Recognition of DNA damage by PCNA-containing replication complex DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation
Drugs
Diseases
GWAS		Acne (severe) ( 24399259) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Feeling lonely ( 29500382) Feeling miserable ( 29500382) High density lipoprotein cholesterol levels ( 33339817) Lymphocyte percentage of white cells ( 32888494) Monocyte percentage of white cells ( 32888494) Neurociticism ( 29500382) Neuroticism ( 29255261) Refractive error ( 32231278) Triglyceride levels ( 32203549)
Interacting Genes		20 interacting genes: ABL1 AR CUL4A CUL4B DCLRE1C DDB1 E2F1 H2AC20 H3C14 HDAC1 NR5A2 NTMT1 PAQR3 RAD51 SIRT6 TOP1 USP24 USP40 XPA XPC	55 interacting genes: AHR AMBRA1 APP AR BRWD1 BRWD3 CAND1 COMMD1 COP1 COPS2 COPS5 CRBN CUL4A DCAF10 DCAF11 DCAF12 DCAF15 DCAF16 DCAF17 DCAF4 DCAF5 DCAF6 DCUN1D1 DCUN1D4 DDA1 DDB1 DDB2 DET1 DNMT3B DTL ERCC8 ESR1 GLMN HUWE1 KPNA2 KPNA4 KPNB1 NEDD8 PHIP PLS3 PRDX3 PTEN PWP1 RBX1 RNF7 SALL2 SIN3A SRC ST7 TBL3 TRPC4AP UBC UBE2D3 WDTC1 ZMAT4
Entrez ID		1643	8450
HPRD ID		02886	02251
Ensembl ID		ENSG00000134574	ENSG00000158290
Uniprot IDs		Q92466	K4DI93 Q13620
PDB IDs		3EI4 3I7L 4E54 4E5Z 6R8Y 6R8Z 6R90 6R91 6R92	2DO7 4A0C 4A0L 4A64
Enriched GO Terms of Interacting Partners?
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