DDB2 and DCLRE1C

Number of citations of the paper that reports this interaction (PubMedID 22134138)
12

Data Source:
BioGRID (pull down)

		DDB2	DCLRE1C
Description		damage specific DNA binding protein 2	DNA cross-link repair 1C
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cell Junction Cul4B-RING E3 Ubiquitin Ligase Complex Protein-containing Complex Cul4-RING E3 Ubiquitin Ligase Complex	Nucleoplasm Golgi Apparatus Nonhomologous End Joining Complex
	Molecular Function	DNA Binding Damaged DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Protein-containing Complex Binding	Single-stranded DNA Endodeoxyribonuclease Activity Damaged DNA Binding Endonuclease Activity Protein Binding 5'-3' Exonuclease Activity 5'-3' Exodeoxyribonuclease Activity
	Biological Process	Protein Polyubiquitination DNA Repair Nucleotide-excision Repair Pyrimidine Dimer Repair Response To UV Histone H2A Monoubiquitination Protein Autoubiquitination UV-damage Excision Repair	Adaptive Immune Response Double-strand Break Repair Via Nonhomologous End Joining Response To Ionizing Radiation B Cell Differentiation Protection From Non-homologous End Joining At Telomere V(D)J Recombination Interstrand Cross-link Repair Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Ub-specific processing proteases DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER TP53 Regulates Transcription of DNA Repair Genes Neddylation	Nonhomologous End-Joining (NHEJ)
Drugs
Diseases
GWAS		Acne (severe) ( 24399259) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Feeling lonely ( 29500382) Feeling miserable ( 29500382) High density lipoprotein cholesterol levels ( 33339817) Lymphocyte percentage of white cells ( 32888494) Monocyte percentage of white cells ( 32888494) Neurociticism ( 29500382) Neuroticism ( 29255261) Refractive error ( 32231278) Triglyceride levels ( 32203549)	Lymphocyte counts ( 32888494) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)
Interacting Genes		20 interacting genes: ABL1 AR CUL4A CUL4B DCLRE1C DDB1 E2F1 H2AC20 H3C14 HDAC1 NR5A2 NTMT1 PAQR3 RAD51 SIRT6 TOP1 USP24 USP40 XPA XPC	10 interacting genes: ATM ATR BRCA1 CDKN1B DDB2 MRE11 NBN PRKDC RAD50 TP53BP1
Entrez ID		1643	64421
HPRD ID		02886	05817
Ensembl ID		ENSG00000134574	ENSG00000152457
Uniprot IDs		Q92466	B3KMX5 Q96SD1
PDB IDs		3EI4 3I7L 4E54 4E5Z 6R8Y 6R8Z 6R90 6R91 6R92	3W1B 3W1G 4HTP 6TT5 6WNL 6WO0 7AF1 7AFS 7AFU 7AGI 7APV
Enriched GO Terms of Interacting Partners?
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