CTSD and PSAP

Number of citations of the paper that reports this interaction (PubMedID 12083803)
9

Data Source:
HPRD (in vivo)

		CTSD	PSAP
Description		cathepsin D	prosaposin
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Lysosomal Membrane Endosome Membrane Specific Granule Lumen Melanosome Lysosomal Lumen Membrane Raft Collagen-containing Extracellular Matrix Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Lysosome Lysosomal Membrane Late Endosome Plasma Membrane Azurophil Granule Membrane Lysosomal Lumen Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Aspartic-type Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Aspartic-type Peptidase Activity	Protease Binding Protein Binding Phospholipid Binding Enzyme Activator Activity Protein Homodimerization Activity Scaffold Protein Binding Ganglioside GM1 Binding Ganglioside GM2 Binding Ganglioside GM3 Binding Ganglioside GT1b Binding Ganglioside GP1c Binding
	Biological Process	Proteolysis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Lipoprotein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Establishment Of Protein Localization	Sphingolipid Metabolic Process Lysosomal Transport Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Autophagy Regulation Of Lipid Metabolic Process Prostate Gland Growth Epithelial Cell Differentiation Involved In Prostate Gland Development Positive Regulation Of Beta-galactosidase Activity Ganglioside GM1 Transport To Membrane
Pathways		Collagen degradation Metabolism of Angiotensinogen to Angiotensins MHC class II antigen presentation Neutrophil degranulation Estrogen-dependent gene expression	Platelet degranulation Glycosphingolipid metabolism Peptide ligand-binding receptors G alpha (i) signalling events Neutrophil degranulation
Drugs		Insulin pork S-Methylcysteine 1h-Benoximidazole-2-Carboxylic Acid 2-Morpholinoethylamine 5-AMINO-6-CYCLOHEXYL-4-HYDROXY-2-ISOBUTYL-HEXANOIC ACID CYCLOHEXYLMETHYL-2,3-DIHYDROXY-5-METHYL-HEXYLAMIDE	Di-Stearoyl-3-Sn-Phosphatidylethanolamine
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Logical memory (delayed recall) in mild cognitive impairment ( 29274321)	Asthma (childhood onset) ( 23829686) Seasonality and depression ( 30217971)
Interacting Genes		25 interacting genes: APP BGLAP CCL21 CD4 CST3 CSTB CTSB FN1 HSPB2 IGF2R IGFBP3 IGFBP4 INS MAPK1 MAPT NEAT1 NLGN3 OGT PSAP SERPINA4 SHBG SLC2A4 SNCA SPRED2 TG	21 interacting genes: APPBP2 BACE1 BRCA1 CD1B CELSR1 COPS6 CPEB2 CTSD ERBB2 GBA MAFF NLGN3 PEX5 PRAG1 SGCG SMAD2 SMAD9 TOMM70 UBE3A USP4 ZBED1
Entrez ID		1509	5660
HPRD ID		00291	01460
Ensembl ID		ENSG00000117984	ENSG00000197746
Uniprot IDs		P07339 V9HWI3	A0A024QZQ2 P07602
PDB IDs		1LYA 1LYB 1LYW 4OBZ 4OC6 4OD9	1M12 1N69 1SN6 2DOB 2GTG 2QYP 2R0R 2R1Q 2RB3 2Z9A 3BQP 3BQQ 4DDJ 4UEX 4V2O 6SLR
Enriched GO Terms of Interacting Partners?
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