CTSD and CSTB

Number of citations of the paper that reports this interaction (PubMedID 3261170)
6

Data Source:
HPRD (in vitro)

		CTSD	CSTB
Description		cathepsin D	cystatin B
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Lysosomal Membrane Endosome Membrane Specific Granule Lumen Melanosome Lysosomal Lumen Membrane Raft Collagen-containing Extracellular Matrix Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Nucleus Nucleolus Cytoplasm Cytosol Secretory Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Aspartic-type Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Aspartic-type Peptidase Activity	Protease Binding RNA Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity
	Biological Process	Proteolysis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Lipoprotein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Establishment Of Protein Localization	Adult Locomotory Behavior Negative Regulation Of Peptidase Activity Negative Regulation Of Endopeptidase Activity Negative Regulation Of Proteolysis
Pathways		Collagen degradation Metabolism of Angiotensinogen to Angiotensins MHC class II antigen presentation Neutrophil degranulation Estrogen-dependent gene expression	Neutrophil degranulation
Drugs		Insulin pork S-Methylcysteine 1h-Benoximidazole-2-Carboxylic Acid 2-Morpholinoethylamine 5-AMINO-6-CYCLOHEXYL-4-HYDROXY-2-ISOBUTYL-HEXANOIC ACID CYCLOHEXYLMETHYL-2,3-DIHYDROXY-5-METHYL-HEXYLAMIDE	Cupric Chloride
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Logical memory (delayed recall) in mild cognitive impairment ( 29274321)	Blood protein levels in cardiovascular risk ( 28369058)
Interacting Genes		25 interacting genes: APP BGLAP CCL21 CD4 CST3 CSTB CTSB FN1 HSPB2 IGF2R IGFBP3 IGFBP4 INS MAPK1 MAPT NEAT1 NLGN3 OGT PSAP SERPINA4 SHBG SLC2A4 SNCA SPRED2 TG	11 interacting genes: COL6A1 CST3 CTSB CTSD CTSH CTSL ECT2 ERG RAD21 RUNX1 SPRY2
Entrez ID		1509	1476
HPRD ID		00291	03091
Ensembl ID		ENSG00000117984	ENSG00000160213
Uniprot IDs		P07339 V9HWI3	P04080 Q76LA1
PDB IDs		1LYA 1LYB 1LYW 4OBZ 4OC6 4OD9	1STF 2OCT 4N6V
Enriched GO Terms of Interacting Partners?
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