CTSD and CST3

Number of citations of the paper that reports this interaction (PubMedID 2013314)
20

Data Source:
HPRD (in vitro)

		CTSD	CST3
Description		cathepsin D	cystatin C
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Lysosomal Membrane Endosome Membrane Specific Granule Lumen Melanosome Lysosomal Lumen Membrane Raft Collagen-containing Extracellular Matrix Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Plasma Membrane Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Aspartic-type Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Aspartic-type Peptidase Activity	Amyloid-beta Binding Protease Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity Identical Protein Binding
	Biological Process	Proteolysis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Lipoprotein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Establishment Of Protein Localization	Defense Response Negative Regulation Of Peptidase Activity Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Endopeptidase Activity Regulation Of Tissue Remodeling Negative Regulation Of Proteolysis Negative Regulation Of Elastin Catabolic Process Negative Regulation Of Blood Vessel Remodeling Supramolecular Fiber Organization
Pathways		Collagen degradation Metabolism of Angiotensinogen to Angiotensins MHC class II antigen presentation Neutrophil degranulation Estrogen-dependent gene expression	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation Amyloid fiber formation
Drugs		Insulin pork S-Methylcysteine 1h-Benoximidazole-2-Carboxylic Acid 2-Morpholinoethylamine 5-AMINO-6-CYCLOHEXYL-4-HYDROXY-2-ISOBUTYL-HEXANOIC ACID CYCLOHEXYLMETHYL-2,3-DIHYDROXY-5-METHYL-HEXYLAMIDE
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Logical memory (delayed recall) in mild cognitive impairment ( 29274321)	Blood protein levels ( 28240269) Chronic kidney disease ( 20383146) Cystatin C levels ( 17903292) Glomerular filtration rate (cystatin C) ( 28452372) Plasma cystastin c levels in acute coronary syndrome ( 24952865)
Interacting Genes		25 interacting genes: APP BGLAP CCL21 CD4 CST3 CSTB CTSB FN1 HSPB2 IGF2R IGFBP3 IGFBP4 INS MAPK1 MAPT NEAT1 NLGN3 OGT PSAP SERPINA4 SHBG SLC2A4 SNCA SPRED2 TG	10 interacting genes: ATXN1 C4A CSTB CTSB CTSD CTSL CTSS PDZD2 POLE3 RNF115
Entrez ID		1509	1471
HPRD ID		00291	05056
Ensembl ID		ENSG00000117984	ENSG00000101439
Uniprot IDs		P07339 V9HWI3	A0A0K0K1J1 P01034
PDB IDs		1LYA 1LYB 1LYW 4OBZ 4OC6 4OD9	1G96 1R4C 1TIJ 3GAX 3NX0 3PS8 3QRD 3S67 3SVA 6ROA 6RPV
Enriched GO Terms of Interacting Partners?
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