PRICKLE1 and LRRK2

PRICKLE1

LRRK2

Description prickle planar cell polarity protein 1 leucine rich repeat kinase 2
Image No pdb structure
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229)
  • Blood urea nitrogen levels ( 31152163)
  • Colorectal cancer ( 30529582 31826910)
  • Endometrial cancer (Non-endometrioid histology) ( 30093612)
  • Graves' disease ( 22922229)
  • Heart failure ( 20445134)
  • Hip circumference adjusted for BMI ( 28552196)
  • Impulsivity (non-planning) ( 30718321)
  • Inferior parietal cortex volume ( 31530798)
  • Multiple sclerosis ( 31604244)
  • Night sleep phenotypes ( 27126917)
  • Parkinson's disease ( 27182965)
  • Refractive error ( 32231278)
  • Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes 14 interacting genes: ANO6 ARID2 BYSL CECR2 HIP1R JRK KIF9 LRRK2 PPP3CB PRPF31 SMURF2 TYR UTP14C VIP 146 interacting genes: ABLIM1 ACTB AFF4 AHCYL1 AHDC1 AKT1 ANKS4B ANO6 APEX2 APP ARFGAP1 ARHGEF7 AURKB BAG1 BAG2 BAG3 C18orf25 C1orf87 CAMK1D CBLB CCDC43 CDC42EP3 CDKL3 CETN3 CHGB CRMP1 CUEDC1 CXCL11 CYREN DBF4B DDIT4 DIDO1 DUX3 DVL1 DVL2 DVL3 DYRK2 E2F4 ECHS1 EIF4EBP1 ENKUR ESRRG FAM184A FAM47B FAM90A1 FANCM FCHSD1 GTSF1 HIF1A HSPD1 ITGB3BP JHY KCTD18 KDM4D KLC2 L3MBTL3 LARP4 LARP7 LATS1 LGALS8 LINC01139 LRP6 MAP1B MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAPT MATK MBP MLLT3 MRGBP MRPL19 MRPL28 MTA1 MYL9 NCBP3 NDUFAF7 NEK1 NSL1 PADI4 PDCL PHF20L1 PIK3CB PIK3R1 PLK1 POLR2M POU5F1 PPP1R8 PRICKLE1 PRKCZ PSME3IP1 PTPN23 RAB11FIP2 RAD51AP1 RALYL RAPGEF4 RASL11B RBIS RHBDD1 RIPK2 RIT1 RPAP3 RPS6KB2 SCEL SERF1A SH3GL2 SH3GL3 SKA3 SMTNL2 SPATS2 SQSTM1 STAC STK24 STK25 STK3 STK40 STN1 STRBP STUB1 SUPT4H1 SYNJ1 TAOK3 TAS2R60 TBC1D22B TCEA2 TCP10L TGIF2LX TRAF2 TTC27 TTLL1 TUBA1A UBXN10 UFD1 UQCRB USP39 VASH2 VGLL4 VN1R1 WSB1 WT1-AS XIRP2 ZAP70 ZFAND5 ZMYM5 ZRANB2
Entrez ID 144165 120892
HPRD ID 16341 10613
Ensembl ID ENSG00000139174 ENSG00000188906
Uniprot IDs A0A024R0W7 B3KVG3 B3KVG6 Q96MT3 Q17RV3 Q5S007
PDB IDs 2ZEJ 3D6T 5MY9 5MYC 6DLO 6DLP 6OJE 6OJF 6VNO 6VP6 6VP7 6XR4
Enriched GO Terms of Interacting Partners?
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